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Peripheral Dopaminergic Receptors contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held in Strasbourg, France, on July 24-25, 1978. The papers explore advances that have been made in understanding peripheral dopaminergic receptors and cover topics organized around five themes: dopamine measurement; structure-activity relationships; peripheral actions of dopamine; effects of dopamine on the kidney; and the physiological role of dopamine in the autonomic nervous system.
This volume is comprised of 36 chapters and opens with a discussion on the dopamine vascular receptor, along with its agonists and antagonists. The reader is then introduced to the physiological and clinical implications of free and conjugated dopamine; dopamine-sensitive adenylate cyclase in the renal artery of dogs; dopamine-induced relaxation of isolated dog arteries; and concentration and function of dopamine in normal and diseased blood vessels. The following chapters explore the possible involvement of endogenous substances in the cardiovascular actions of dopamine; the role of dopamine receptors as mediators of the neurogenic vasodilatation by dopaminergic agents; and implications of renal and adrenal dopamine for the role of conjugated dopamine. Studies on the peripheral cardiovascular activity of dopamine in the rat are also presented.
This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.
Contenu
Preface
Chapter 1: Introductory Lecture The Dopamine Vascular Receptor: Agonists and Antagonists
Dopamine Measurement
Chapter 2: Free and Conjugated Dopamine; Physiological and Clinical Implications
Chapter 3: Tissue Dopamine Levels as an Indicator of Tyrosine Hydroxylase Activity
Chapter 4: A Mass Fragmentographic Assay of Human Plasma Catecholamines
Chapter 5: Histochemical and Biochemical Estimations of Dopamine in Postganglionic Autonomic Nerves
Chapter 6: Discussion
Structure âEUR Activity Relationship
Chapter 7: Structure-Activity and Conformational Requirements for Dopaminergic Agonists; Comparison of Central and Peripheral Dopamine Receptors
Chapter 8: Structure-Activity Relationships at Dopaminergic Receptors
Chapter 9: Dopamine Congeners Derived from the Benzo(f)-quinoline Ring
Chapter 10: Dopamine 3-0-sulfate, a Direct Precursor of Free Norepinephrine; an Alternative Biosynthetic Pathway?
Chapter 11: Dopamine-sensitive Adenylate Cyclase in Canine Renal Artery
Chapter 12: Discussion
Peripheral Actions of Dopamine (except Kidney)
Chapter 13: Dopamine and Chronic Auriculo-ventricular Heart-block in the Unanaesthetized Dog
Chapter 14: α- and β-adrenoceptors but not Dopaminergic Receptors are Involved in the Positive Inotropic Action of Dopamine in the Rabbit Heart
Chapter 15: Dopamine-induced Relaxation of Isolated Dog Arteries
Chapter 16: In Vitro Study with Semi-rigid Rotameric Conformational Analogs of Dopamine
Chapter 17: Effects of Several Central Dopamine Receptor Stimulants on Mesenteric Arterial Blood Flow in Anesthetized Dogs
Chapter 18: Vasodilatation Produced by Apomorphine in the Hindleg of the Dog
Chapter 19: Dopaminergic Receptors in the Coronary Arteries
Chapter 20: Concentration and Function of Dopamine in Normal and Diseased Blood Vessels
Chapter 21: Possible Involvement of Endogenous Substances in the Cardiovascular Actions of Dopamine
Chapter 22: Species Differences of Dopaminergic Vasodilation in the Intestine
Chapter 23: Search for a Serotoninergic Mechanism in the Pharmacological Effects of Dopamine on Motricity in the Isolated Rat Duodenum
Chapter 24: Effects of Dopamine on the Cerebral Circulation
Dopamine and Autonomie Nervous System
Chapter 25: Physiological and Pharmacological Role of the Regulation of Noradrenaline Release by Presynaptic Dopamine Receptors in the Peripheral Nervous System
Chapter 26: The Inhibitory Neurogenic Effects of N-N-di-n-Propyl Dopamine: a Vascular Dopamine Agonist
Chapter 27: Action of Piribedil on Presynaptic Dopamine Receptors at Postganglionic Sympathetic Nerve Terminals
Chapter 28: Characteristics of Apomorphine Tachyphylaxis
Chapter 29: Inhibitory Receptors on the Adrenergic Nerve Terminal
Chapter 30: The Role of a Ca++ Dependent Protein Activator Purified from Brain in the Regulation of Dopamine Receptors
Chapter 31: Evidence that Dopamine Receptors Mediate the Neurogenic Vasodilatation by Dopaminergic Agents
Chapter 32: Role of Dopamine in the Modulation of Norepinephrine Release from the Rat Portal Vein
Chapter 33: Selective Prevention of Bethanechol-induced Decrements of Histofluorescence in Sympathetic Ganglia
Dopamine and the Kidney
Chapter 34: Renal Dopaminergic Mechanisms
Chapter 35: Effect of Dopamine on Renin Release from the Isolated Perfused Rat Kidney
Chapter 36: Renal and Adrenal Dopamine Balance: Implications for the Role of Conjugated Dopamine
Chapter 37: L-γ-Glutamyl Dopamine, an Oral Dopamine Prodrug with Renal Selectivity
Chapter 38: Regulation of Renal Function by Endogenous Dopamine
Chapter 39: Studies on the Peripheral Cardiovascular Activity of Dopamine in the Rat
Chapter 40: Concluding Remarks
Index