Pathogenicity Islands and the Evolution of Pathogenic Microbes

It has been known for a number of years that not only pathogenicity islands but also plasmids and bacteriophages are able to carry genes whose products are involved in pathogenic processes. Accordingly, such elements and their products play an important role in pathogenesis due to the intestinal E. coli as well due to Shigellae. Another interesting aspect which is reflected in different articles is that genomes evolve by acquisition of new pieces of DNA following gene transfer, but also by genome reduction. Different mechanisms include the deletion of sequences or the elimination of functions by the accumulation of point mutations or rearrangements.

Contenu

Evolution of prokaryotic genomes.-Extraintestinal Escherichia coli as a model system for the study of pathogenicity islands.-Pathogenicity islands fo intestinal E. coli.-Pathogenicity islands of Shigella.-Pathogenicity islands and host adaptation of Samonella serovars.-Plasmids and pathogenicity islands of Yersinia.-Genomic structure of LPS-specific loci.-Genomic structure of capsular determinants.-Genome Plasticity of Pathogenic and Non-Pathogenic Enterobacteria.-Phylogenetic Relationships and Virulence Evolution in the Genus Bordetella.-Pathogenicity Islands and PAI-Like Structures in Pseudomonas Species.-Subject Index