Nucleic Acids in Medicinal Chemistry and Chemical Biology

Nucleic Acids in Medicinal Chemistry and Chemical Biology

An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications

In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers.

The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field.

Readers will also find:

• A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry

• Comprehensive explorations of the methods used to determine the development of nucleic acid drugs

• Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries

• In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry

Perfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

Auteur

Lihe Zhang is President of the Academic Committee of State Key Laboratory of Natural & Biomimetic Drugs and Professor of Medicinal Chemistry at Peking University.

Xinjing Tang is Professor of Medicinal Chemistry at Peking University.

Zhen Xi is Chairman of the Department of Chemical Biology, Deputy Director of the State Key Laboratory of Element-Organic Chemistry, Professor of Pesticide Science and Chemical Biology, and Vice Dean for Academic Affairs of the College of Chemistry at Nankai University.

Jyoti Chattopadhyaya is Chairman of the Department of Cell and Molecular Biology and Chair of Bioorganic Chemistry at the University of Uppsala.