Non-coding RNAs in the Vasculature

This book focuses on the importance of regulatory RNAs in the vasculature. The main topics discussed include the role of regRNAs in vascular development and angiogenesis, ischemic cardiovascular disease and repair mechanisms, diabetic and metabolic vascular disease, atherosclerosis and vascular inflammation, as well as diagnostics of vascular disease using circulating miRNAs. Lastly, it offers an overview of emerging topics such as microvesicle-mediated miRNA cellular trafficking and the vascular importance of long non-coding RNAs. It is an invaluable resource for academics, researchers and students working in the field of vascular biology.

Auteur
Prof. DDr. Thomas Thum, Institute of Molecular and Translational Therapeutic Strategies Hannover. Medical School Carl-Neuberg Str. 1. 30625 Hannover, Germany Email: Thum.Thomas@mh-hannover.de
Prof. Dr. Stefanie Dimmeler, Institute for Cardiovascular Regeneration Centre of Molecular Medicine, Goethe University Frankfurt. 60590 Frankfurt, Germany Email: dimmeler@em.uni-frankfurt.de

Résumé

This volume describes important functions and roles of micro RNAs in the vasculature in health, disease, therapeutics and diagnostics. It shows how miRNAs can be used to improve stem cell-based regenerative therapies of cardiovascular diseases; further the role of miRNAs as regulators in lipoprotein metabolism in the liver and reverse cholesterol transport is depicted, as well as their pathological function in diabetes and atherosclerosis. The book discusses the use of circulating miRNAs as disease biomarkers and shows interesting correlations with the amount of detectable miRNAs in the blood and future cardiovascular risks.

This book is edited and written by leading figures in the field and will be an invaluable resource for academics, researchers and students working on non-coding RNAs in biomedicine, physiology and vascular biology.

Contenu

1. Non-coding RNAs in the vasculature.- Introduction (Thomas Thum, Stefanie Dimmeler).- Non-coding RNAs in vascular Development and Angiogenesis (Nathan Lawson or Didier Steinier).- 2. Diagnostics of Vascular Diseases using circulating miRNAs.- 2.1 Basic and Technical Principles (Manuel Mayr).- 2.2 Diagnostics use of circulating miRNAs in cardiovascular diseases (Andreas Zeiher , Stephan Fichtlscherer).- 2.3 Non-coding RNAs in Ischemic cardiovascular disease and repair mechanisms (incl. AMI, cell therapy) (Ulf Landmesser).- 3. Non-coding RNas in Diabetes and Metabolic Diseases.- 3.1 Non-coding RNAs in vascular complications of Diabetes (Costanza Emanueli).- 3.2 Non-coding RNAs in Metabolic Diseases, Cholesterol Metabolism (Carlos Fernandez-Hernando).- 3.3 Non-coding RNAs in Atherosclerosis and Vascular Inflammation (incl. aging processes and aneurysms, platelelets)(Christian Weber, Feinberg).- 4. Outlook and Perspectives (long non coding RNAs, microvesicles, new therapies,ect) (Thomas Thum, Stefanie Dimmeler).