Neurochemistry of the Retina

Neurochemistry of the Retina covers the proceedings of the International Symposium on the Neurochemistry of the Retina held in Athens, Greece, on August 28 - September 1, 1979. This book mainly focuses on the retina and its neurochemistry.
This text is divided into eight major parts. The first part discusses the composition, metabolism, and biogenesis of membrane components. This book then explains the biochemical approaches to the study of visual cells and their relationship with the pigment epithelium, photorector shedding, and circadian rhythm. Chemical transmission of nerve signals is also tackled. This text also looks into the biochemical aspects of photoreceptor structure and function; cyclic nucleotides; and biochemical and pharmacological approaches to study the entire retina. This book concludes by explaining the neurochemical studies in retinal diseases and future research and prospective of the subject.
This publication will be invaluable to ophthalmologists and students of ophthalmology.

Contenu

I. Composition, Metabolism and Biogenesis of Membrane Components
Transverse Distribution of Phospholipids in the Vertebrate Photo Receptor Membrane
Biosynthesis of Membrane Lipids in the Retina: Sub-cellular Distribution and Propranolol Action on Phosphatidic Acid, Phosphatidylserine and Phosphatidylethanolamine
Synthesis and Turnover of Lipid and Protein Components of Frog Retinal Rod Outer Segments
The Gangliosides of the Chicken Retina and Optic Tectum. The Influence of Light on their Labeling after an Injection of Labeled Precursors
The Lipid Intermediate Pathway in the Retina for the Activation of Carbohydrates Involved in the Glycosylation of Rhodopsin
II. Biochemical Approaches to the Study of Visual Cells and their Relationship with the Pigment Epithelium, Photoreceptor Shedding and Circadian Rhythm
Electrophysiological Responses Related to the Pigment Epithelium and its Interaction with the Receptor Layer
Control of Rod Shedding in the Frog Retina
Retinal Development: Time and Order of Appearance of Specific Neuronal Properties
Cyclic Metabolism of Photoreceptors and Retinal Pigment Epithelium in the Frog
An Hypothesis for a Vitamin A Cycle in the Pigment Epithelium of Bovine Retina
The Chemistry of the Retina: Function, Renewal, Rhythms and the Nucleus
III. Chemical Transmission of Nerve Signals. Localization, Metabolism and Function of Neurotransmitters
Studies on Putative Neurotransmitters in the Distal Retina
The Localization and Metabolism of Glutamate, Aspartate and GABA in the Rat Retina
GABA and Dopamine Receptor Binding in Retinal Synaptosomal Fractions
Retinal Organization: Neurotransmitters as Physiological Probes
The Release of Acetylcholine and Amino Acids from the Rabbit Retina In Vivo
Retinal Indoleamine Accumulating Neurons
IV. Biochemical Aspects of Photoreceptor Structure and Function
The Partial Primary Structure of Bovine Rhodopsin and its Topography in the Retinal Rod Cell Disc Membrane
The Oligosaccharide Moiety of Rhodopsin - Its Structure and Cellular Location
Lectins as Probes of Glycoprotein and Glycolipid Oligosaccharides in Rods and Cones
Light-induced, Reversible Binding of Proteins to Bovine Photoreceptor Membranes. Influence of Nucleotides
Rhodopsin Phosphorylation in the Frog Retina: Analysis by Autoradiography
Search for a Physiological Role of Cyclic GMP Metabolism in the Photoreceptors
V. Cyclic Nucleotides
Localization and Roles of Cyclic Nucleotide Systems in Retina
Cyclic Nucleotides in Rod- and Cone-dominant Retinas
VI. Biochemical and Pharmacological Approaches to Study the Entire Retina
The Isolated Retina of Mammals: A Useful Preparation for Enzymatic (Adenylyl Cyclase) and/or Binding Studies of Dopamine Receptors
ERG Alterations Induced by Sound
The Action of Psychotropic Drugs on Adenylate Cyclases and Phosphodiesterases in the Rat Retina
Composition and Biosynthesis of Molecular Species of Retina Phosphoglycerides
Synthesis and Breakdown of Different Sized Retinal Proteins in Darkness and during Photic Stimulation
VII. Neurochemical Studies in Retinal Diseases
Morphological and Biochemical Abnormalities in a Model of Retinal Degeneration: Canine Ceroid-lipofuscinosis (CCL)
Cyclic GMP Metabolic Defects in Inherited Disorders of RD Mice and RCS Rats
Cyclic GMP Phosphodiesterase Activator: Involvement in a Dereditary Retinal Degeneration
Gyrate Atrophy of the Retina and Choroid is an Inborn Error of Metabolism of Ornithine Aminotransferase
Effects of Exogenous Gangliosides on the Pattern of Respiratory Enzymes in Experimental Diabetic Retinopathy in the Rat
Biochemistry of Retinal Degeneration in Rats and Mice: A Short Review
VIII. Future Research and Prospective from Neurochemical Studies of the Retina in Health and Disease
The Retina as a Biochemical Model of Central Nervous System Regeneration
Acetylcholine in the Retina
Dopaminergic Mechanisms in the Carp Retina: Effects of Dopamine K+ and Light on Cyclic AMP Synthesis
The Disk Membrane as Model for an Excitable Membrane
List of Participants
Authors Index
Subject Index