Neurobiology of Disease

The second edition of Neurobiology of Disease includes nearly 200 articles surveying all major disorders of the nervous system in both adults and children, focusing on relevant diagnosis and treatments from the perspective of cutting edge clinical and basic neurobiological research. Akin to an encyclopedia of every neurologic disorder, this comprehensive work is ideal for graduate and medical school students, residents, and candidates preparing for their board certification examinations. Each chapter is illustrated with detailed figures, supplemented with descriptive and diagnostic tables, and thoroughly referenced for further investigations. The book's editors, Michael V. Johnston, Harold P. Adams Jr., and Ali Fatemi bring their unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this new edition, the following Section Editors provided oversight of their respective sections: ? Movement Disorders-Joel Perlmutter, Washington University ? Dementias-David Knopman, Mayo Clinic ? Motorneuron Diseases-Merit Cudkowicz, Massachusetts General Hospital ? Paroxysmal Disorders-Solomon Moshe, Albert Einstein College of Medicine ? Pediatric Neurology and Developmental Disorders-Tanjala Gipson and Deepa Menon, Kennedy Krieger Institute and Johns Hopkins University ? Neuroimmunological Diseases-Carlos Pardo-Villamizar, Johns Hopkins University ? Cerebrovascular Diseases-Harold P. Adams Jr., University of Iowa ? Peripheral and Autonomic Nervous System Disorders and Pain-Nicholas Maragakis, Johns Hopkins University ? Neoplastic and Paraneoplastic Diseases-Lisa DeAngelis, Memorial Sloan-Kettering Cancer Center ? Infectious Diseases of the Nervous System-Karen L. Roos, Indiana University ? Sleep Disturbances-Mark Dyken, University of Iowa ? Substance Abuse and Toxicology Disorders-Barry E. Kosofsky, Weill-Cornell University Medical Center ? Neurologic Manifestations of Medical Disorders-John C. Probasco, Johns Hopkins University

Auteur

Professor Michael Johnston at Johns Hopkins and the Kennedy Krieger Institute, and Professor Harold Adams at the University of Iowa, are respected international authorities in pediatric neurology and adult neurology, respectively, with substantial records of teaching and scholarship. Dr. Ali Fatemi who trained in pediatric neurology and neurogenetics at Massachusetts General and is head of the Moser Center for Leukodystrophies brings expertise in clinical and research neurogenetics to the editorial team.

Contenu

SECTION I: Movement Disorders (Joel Perlmutter, Washington University) 1. History of Parkinsonism Michael Silver, MD and Stewart A. Factor, DO 2. Parkinson Disease: Pathophysiology, Clinical Manifestations and Course including Diagnosis and Differential Diagnosis Michael J. Soileau, MD and Kelvin L. Chou, MD 3. Parkinson Disease: Treatment, Current Clinical Trials Thien Thien Lim, MD and Hubert H. Fernandez, MD 4. Parkinson Syndromes: Multiple System Atrophy Melvin W. Kong, MD and Ejaz A. Shamim MD, MS 5. Parkinson Syndromes: Progressive Supranuclear Palsy Vikas Kotagal, MD, MS and Praveen Dayalu, MD 6. Parkinson Syndromes: Corticobasal Degeneration Sami Barmada, MD, PhD 7. Huntington Disease: Etiology, Genetics, and Clinical Manifestations Roger L. Albin, MD and Henry L. Paulson, MD, PhD 8. Huntington Disease: Treatment, Current Clinical Trials Charles S. Venuto, PharmD and Karl Kieburtz, MD, MPH 9. Essential Tremors Arif Dalvi, MD, MBA, Kelly E. Lyons, PhD, and Rajesh Pahwa, MD 10. Dystonia: History and Classification H. A. Jinnah, MD, Cecilia N. Prudente, MD, Samuel J. Rose, MD and Ellen J. Hess, MD 11. Dystonia: Pathophysiology, Clinical Manifestations and Course Including Diagnosis, and Differential Diagnosis, Treatment, Current Clinical Trials Jeri Yvonne Williams, MD and David G. Standaert, MD, PhD 12. Paroxysmal Dyskinesias Olga Waln, MD and Joseph Jankovic, MD. 13. The Expanded Polyglutamine Tract Spinocerebellar Ataxias Elsdon Storey, MD 14. Ataxias: Autosomal Recessive and other Ataxias Vikram G. Shakkottai, MD, PhD SECTION II: Dementias (David Knopman, Mayo Clinic) 15. Alzheimer's Disease: Pathology and Pathogenesis Bradley T Hyman, MD, Beatriz G Perez-Nievas, MD, Isabel Barroeta-Espar, MD, Alberto Serrano-Pozo, MD, Matthew Frosch, MD, and Teresa Gomez-Isla, MD 16. Alzheimer's Disease: Clinical Manifestations and Diagnostic/Differential Diagnosis Michael S. Rafii, MD, PhD 17. Alzheimer's Disease: Management and Treatment Gregory A. Jicha, MD, PhD and Frederick A. Schmitt, PhD 18. Frontotemporal Degenerations Jonathan Graff-Radford, MD, and Keith A. Josephs, MD, MST, MSc 19. Diagnosis and Therapy for Lewy Body Dementia Bela R. Turk, MD and Ali Fatemi, MD 20. Pathogenesis of Lewy Body Dementia Jagan A. Pillai, MD, PhD and James B. Leverenz, MD 21. Cerebrovascular Dementia Rahul Karamchandani, MD and Nancy R. Barbas, MD, MSW SECTION III: Motorneuron Diseases (Merit Cudkowicz, Massachusetts General Hospital, Harvard University) 22. Types of MNDS Nimish Thakore, MD and Erik P. Pioro, MD, PhD 23. Clinical Presentations, Diagnostic Criteria, Lab Testing Nimish Thakore, MD and Erik P. Pioro, MD, PhD 24. Symptomatic Care Matthew Gladman, MD and Lorne Zinman, MD, MSc 25. ALS: Epidemiology Éilis J. O'Reilly, ScD 26. ALS: Pathogenesis Laura Ferraiuolo, MD and Stephen J. Kolb, MD 27. ALS: Insights from Genetics Matthew B. Harms, MD and Timothy M. Miller, MD, PhD 28. ALS: In Vitro and In Vivo Disease Models Brian J. Wainger, MD, PhD 29. ALS Pathology Brent T. Harris, MD, PhD, Galam A. Khan, MD, and Saed Sadeghi, MD 30. ALS: Clinical Trials Past Reflections Informing New Directions Katharine A. Nicholson, MD and James D. Berry, MD 31. Upper Motor Neuron Disorders: Hereditary Spastic Paraplegia and Primary Lateral Sclerosis John K. Fink, MD 32. UMN Disorders (HSP and PLS): Pathogenesis, Insights from Genetics, In Vitro and In Vivo Disease Models, Pathology and Clinical Trials Sabrina Paganoni, MD, PhD and Nazem Atassi, MD, MMSc 33. SMA: Pathogenesis Umrao R. Monani, PhD and Darryl C. De Vivo, MD 34. SMA: Insights from Genetics Arthur H.M. Burghes, MD and Vicki L. McGovern, MD 35. SMA: In Vitro and In Vivo Models of Spinal Muscular Atrophy W. David Arnold, MD and Arthur H.M. Burghes, MD SECTION IV: Paroxysmal Disorders (Solomon Moshe, Albert Einstein College of Medicine) 36. Biological Basis of Primary Generalized Epilepsies-Genetics Carla Marini, MD and Renzo Guerrini, MD 37. Biological Basis of Primary Generalized Epilepsies - Pathophysiology Mark W. Youngblood, MD and Hal Blumenfeld, MD 38. Temporal Lobe Epilepsy Edward H. Bertram, MD 39. Focal Cortical Dysplasias Ali Mahta, MD and Peter B. Crino, MD, PhD 40. Biological Bases of Symptomatic Generalized Epilepsies in Children Dragos A. Nita, MD, Miguel A. Cortez, MD, Jose Luis Perez Velazquez, MD, and O. Carter Snead 3rd, MD 41. Epilepsies that Occur Predominantly in Girls Lynette G Sadleir, MD, Jozef Gecz, MD, and Ingrid E Scheffer, MD 42. Epidemiology of Epilepsy: Incidence, Prevalence, and Risk Factors Dale C Hesdorffer, PhD, MPH 43. Clinical Presentation, Diagnosis, and Course- Epilepsy Syndromes with Focal Seizures Alex Boro, MD and Jerome Engel, Jr., MD 44. Medical Management of Epilepsy Jules C. Beal, MD and Emilio Perucca, MD 45. Neuroimaging in Epilepsy William A. Gomes, MD, PhD 47. Alternative Therapies for Epilepsy: Dietary Treatments Carl E. Stafstrom, MD, PhD 48. Migraine and Other Headache Disorders Robert W. Charlson, MD and Matthew S. Robbins, MD 49. Neurobiology of Migraine Victor Rosenfeld, MD and John Stern, MD SECTION V: Pediatric Neurology and Developmental Disorders (Tanjala Gipson and Deepa Menon, Kennedy Krieger Institute and Johns Hopkins University) 50. Autism and Intellectual Disabilities: Overview of Autism and Intellectual Disabilities Tanjala T. Gipson, MD and Michael V. Johnston, MD 51. Tuberous Sclerosis Complex: Pediatric Aspects Tanjala T. Gips…