Myocardial Infarction And Cardiac Death

Medicinal Chemistry, Volume 18: Myocardial Infarction and Cardiac Death focuses on the prevention and treatment of myocardial infarction. This book explores the synthesis and biological evaluations of hypolipidemic agents.
Organized into seven chapters, this volume starts with an overview of the anatomical and functional characteristics of the blood vessels, which is important in understanding the effect on the microcirculation of alterations in blood flow as would occur in myocardial infarction. This text then explores the two serious consequences that result from occlusion of the coronary arteries and the resultant myocardial infarction, namely, the failure of the heart as pump and the development of life-threatening arrhythmias. Other chapters review the medical treatment for primary and secondary prevention of myocardial infarction and sudden death. The final chapter deals with the interventions in the prevention of myocardial infarction, including drug therapy, surgical procedures, and lifestyle modifications.
This book is a valuable resource for cardiologists and other health professionals.

Contenu

In Memoriam

Contributors

Preface

1. Role of the Microvasculature in Myocardial Infarction

   I. The Microvasculature of the Myocardium

   II. Microcirculation in Myocardial Infarction

   References

2. Animal Studies in Artificially Induced Myocardial Infarction

   I. Introduction

   II. Methods of Producing Coronary Artery Occlusion

   III. Ventricular Arrhythmia Associated with Myocardial Infarction

   IV. Ischemia and Infarction

   V. Summary

   References

3. Pharmacologic Approaches to the Prevention of Myocardial Infarction and Sudden Death

   I. Introduction

   II. ß-Adrenoceptor Blocking Drugs

   III. Lipid-Lowering Agents

   IV. Vitamin

   V. Anticoagulation Therapy (Heparin and Sodium Warfarin)

   VI. Anticoagulation (Antiplatelet Agents)

   VII. Coronary Artery Surgery

   VIII. Summary

   References

4. Pharmacology of Antiplatelet Agents and Their Role in Coronary Disease

   I. Summary of Clinical Trials of Antiplatelet Agents

   II. Thrombus Formation in Arteries

   III. Thromboembolism and Clinical Complications of Coronary Disease

   IV. Effects of Substances Produced by Injured Vessel Walls

   V. The Role of Platelets in the Initiation of Coronary Artery Disease

   VI. Tests of the Effects of Drugs on Platelet Reactions

   VII. Drugs That Inhibit Platelet Reactions

   References

5. Platelets, Thrombosis, Atherosclerosis in Myocardial Infarction: Interactions and Relationships

   I. Introduction

   II. Platelets and Thrombosis in Atherogenesis

   III. Thrombosis in Progression of Atherosclerosis

   IV. Thrombotic Complications of Atherosclerosis

   V. Coronary Occlusion, Thromboembolism, and Cardiac Death

   VI. Summary

   References

6. Clinical Pathogenesis and Physiological Processes Involved in Myocardial Infarction and Sudden Cardiac Death

   I. Introduction

   II. The Clinical Setting of Sudden Death

   III. Pathology of Sudden Death

   IV. The Clinical Precursors of Sudden Death

   V. Mechanism of Sudden Death

   VI. Metabolic and Electrophysiologic Mechanisms

   VII. Central and Autonomic Nervous Systems and Sudden Death

   References

7. Considerations in the Design, Execution, and Interpretation of Clinical Trials in Cardiac Mortality

   I. Introduction

   II. Methodological Standards in Clinical Trials

   III. Considerations for the Design of Future Studies

   IV. Multiple Analysis

   V. Summary

   References

Index