This book summarizes the latest research trends in phytophenolic therapy for the management of diabetes. It discusses the various mechanisms of action of phytophenolics present in food, fruits and plants that can be used to control/reverse diabetic conditions. Further, it addresses the synergistic interactions of phytophenolics with anti-diabetic drugs, as understanding them can yield valuable insights for complementary and alternative medicine. In closing, it discusses the important aspects of nanotechnology-based targeted delivery and improving the bioavailability of phenolic phytochemicals, two major areas of research in phytotherapy of diabetes.

Auteur

Muddasarul Hoda Assistant Professor, Department of Biological Sciences, Aliah University, Kolkata. His research interests include nanotechnology in drug targeting and therapeutics, and synergism of phytochemicals against glucose homeostasis imbalance and cancer. He received his PhD from Pondicherry University, and postdoctoral degree from the IIT Madras. He has 7 research publications to his credit.

Shanmugam Hemaiswarya Project Officer, Department of Biotechnology, Indian Institute of Technology, Madras. Her research interests include phytomedicine and studying combinations of phytochemicals with synthetic drugs as effective antibacterial and anticancer agents. She engaged in a two-year postdoctoral stay at the University of Algarve, Portugal and a three-year research fellowship under Women Scientist Scheme A (DST). She has 19 research publications to her credit.

Mukesh Doble is a Professor (Emeritus) at the Department of Biotechnology, IIT Madras, Chennai, India. His areas of interest include drug design, natural products and biomaterials. He has previously worked for 23 years in Imperial Chemical Industries (ICI) and General Electric (GE) Technology centres. He holds BTech and MTech degrees in Chemical Engineering from the IIT Madras, a PhD from the University of Aston, UK, and postdoctoral degrees from the University of Cambridge, UK, and Texas A&M, USA. He has authored 310 technical papers, 10 books, and filed 12 patents. He is a fellow of the Royal Society of Chemistry and a recipient of the Herdillia Award for Excellence in Basic Research from the Indian Institute of Chemical Engineers. He received the 5th National Award for Technology Innovation in the Field of Petrochemicals and Downstream Plastic Processing Industry, Govt of India for his innovations in Antimicrobial Food Wrap (Runner up, 2015). He is also the Director of two biotech start-ups.

Contenu

Diabetes: Its Implications, Diagnosis, Treatment & Management.- Phenolic Phytochemicals- Sources, biosynthesis, extraction and their isolation.- Food sources of Anti-Diabetic Phenolic Compounds.- Mechanisms of Action of Phenolic Phytochemicals in Diabetes Management.- Synergistic Behaviour of Phytophenolics with Anti-Diabetic Drugs.- Polyphenol Nanoformulations with Potential Antidiabetic Properties.- Pharmacokinetics and Pharmacodynamics of Polyphenols.- Trends in Research and Development of Phenolic Phytochemicals as Potential Anti-Diabetic Therapeutics.- Conclusions.