Monoamine Oxidase Enzymes

The papers in this volume are the invited lectures at the Second Workshop on Amine Oxidases held at the Biomedical Center, Uppsala University, 2 to 4 August 1986. It was a great pleasure for the organizers to see, in Uppsala, so many old and new friends, all brought together by our common interest in the fascinating field of Amine Oxidases. The Workshop was the successor of a long row of successful predecessors to start with the 1972 meeting in Cagliari, Sardinia, and recently preceded by the first meeting of Workshop design, held in Cambridge 1984. Several of the previous meetings have been dedicated to distinguished senior research workers within the field. To start this Workshop a memorial lecture was given. This lecture, given by Prof. T. P. Singer, was dedicated to the late Prof. K. Kamijo, who was one of the pioneers of what is now worldwide interest in Amine Oxidases and who organized the superb meeting in Hakone 1981. To the great honour of all the participants the family of the late Prof. Kamijo visited the Workshop. Abstracts of all the presentations have been published as a Supplement of Acta Pharmacologica et Toxicologica (Copenhagen).

Contenu

Perspectives in MAO: past, present and future. A review.- The catalytic behaviour of monoamine oxidase.- Some properties of semicarbazide-sensitive amine oxidases.- Amine oxidases and their endogenous substrates (with special reference to monoamine oxidase and the brain).- Processing of MPTP by monoamine oxidases: implications for molecular toxicology.- The functional coupling of neuronal and extraneuronal transport with intracellular monoamine oxidase.- Overview of the present state of MAO inhibitors.- MAO inhibitors in mental disease: their current status.