Molecular Techniques for the Study of Hospital Acquired Infection

Providing a broad overview of the microbial pathogens associated with hospital-acquired human illness, Techniques for the Study of Hospital Acquired Infection examines the cost-effective use of laboratory techniques in nosocomial infectious disease epidemiology and control. This concise guide addresses the cost benefits of combining modern molecular techniques with the traditional activities of infection control departments. The book is useful as a guide to hospital infection control programs as well as a text for medical practitioners, grad/medical students, researcher scientists, population biologists, molecular biologists, and microbiologists.

Auteur

Shabbir Simjee, Ph.D. is a Senior Microbiologist at Eli Lilly & Company, where he specializes in antimicrobial susceptibility testing and the interpretation of antimicrobial susceptibility data according to NCCLS and BSAC standards. He has served as Editor of The Journal of Antimicrobial Chemotherapy and currently serves as an Editorial Board Member for Antimicrobial Agents and Chemotherapy as well as Section Editor (Molecular Microbiology) for the International Journal of Antimicrobial Agents. Dr. Simjee has served on a number of FDA advisory committees.

Steven Foley, Ph.D. is an Associate Research Scientist for the National Farm Medicine Center, Marshfield Clinic Research Foundation, as well as Clinical Professor of Clinical Microbiology at the University of Wisconsin. His research interests include understanding the mechanisms that Escherichia coli employ to resist being killed by vertebrate immune system constituents and the development and utilization of genotypic and phenotypic methods to track enteric bacterial pathogens and their virulence and antimicrobial resistance factors through the food animal production environment.

Anne Chen, M.D. is a Senior Staff Physician, Division of Infectious Diseases at the Henry Ford Hospital, Detroit, Michigan as well as Assistant Professor of Medicine at Wayne State University School of Medicine. She is Board Certified in Internal Medicine and Infectious Disease and is currently researching Candida epidemiology in the burn unit.

Marcus J. Zervos, M.D. is the Medical Director of Infection Control and Division Head of Infectious Disease, Department of Internal Medicine at Henry Ford Hospital as well as Clinical Professor of Medicine in the Department of Internal Medicine, Infectious Diseases Section at Wayne State University School of Medicine. He chairs the Infection Control Committee at the Henry Ford Hospital and is certified by the American Board of Internal Medicine and Infectious Diseases. Dr. Zervos serves on the boards of several journals in infectious disease, microbiology and internal medicine, including Infectious Diseases in Clinical Practice and his role as Section Editor for the journal Infection Control and Hospital Epidemiology.

Texte du rabat

Latest findings, practices, and strategies to detect and control nosocomial infections

Nosocomial infections, also known as hospital acquired infections, represent a growing challenge to healthcare facilities around the world. Many nosocomial pathogens are becoming more and more resistant to treatment, resulting in higher morbidity, mortality, and cost. In fact, each year it is estimated that some two million patients develop a hospital-acquired infection in the United States, representing nearly 5% of all hospitalized patients.

Molecular Techniques for the Study of Hospital Acquired Infection reviews the latest findings, practices, and strategies to support the development and implementation of effective, comprehensive programs to study and control hospital acquired infections. It focuses on the application of molecular techniques, enabling hospitals to incorporate these state-of-the-technology techniques into their infection control programs.

Key topics include:

• Characteristics of healthcare settings that allow for the development and spread of nosocomial pathogens

• Implementation of effective infection control programs

• Epidemiological methods to study nosocomial disease

• Elimination of pathogens and the development of resistance to treatment

• Molecular techniques to study hospital acquired infections and their application in characterizing important Gram-positive, Gram-negative, and fungal pathogens

Contributions come from leading international experts in nosocomial pathogen detection and control. These contributions are based on the authors' own firsthand experience combined with a thorough review and analysis of the current literature. References at the end of each chapter enable readers to explore each individual topic in greater depth.

Molecular Techniques for the Study of Hospital Acquired Infection is highly recommended as a guide for hospital infection control programs. Moreover, it serves as a text for courses in infection control and the population biology of nosocomial infection. In particular, the book's unique clinical perspective helps readers minimize nosocomial infections by developing a coordinated approach to infection control, laboratory methods, and clinical practices.

Contenu

Contributors.

Forword.

Preface.

Dedication.

I. Introduction to Healthcare Associated Infections and Their
Control.

1. The Hospital and Ambulatory Care Environment (Anne Y. Chen
   and Hiren Pokharma).

2. Pathogen Transmission in the Healthcare Setting (Sonja
   Hansen and Ralf-Peter Vonberg).

3. Infection Control Basics (Louise-Marie Dembry and Carlos
   Torres-Viera).

4. Cost-Effectiveness of IC Program (Marc-Oliver Wright and
   Eli N. Perencevich).

5. Outbreak Investigations (Importance of the Healthcare
   Epidemiologist) (Marcus J. Zervos).

6. Pathogen Elimination: Antibiotic and Disinfectant Use and the
   Development of Resistance (Steven L. Foley, Beilei Ge, Carl M.
   Schroeder, and Arron M. Lynne).

II. Techniques to Characterize Nosocomial Pathogens.

7. Rapid PCR Screening Methods (Ngolela Esther Babady,
   Frankling Cockerill and Robin Patel).

8. Restriction Analysis Techniques (Richard V. Goering, Mary
   Stemper, SanjayShukla and Steven Foley).

9. Pulsed-field Gel Electrophoresis (Mary Stemper, Steven
   Foley Richard V. Goering, and Sanjay Shukla).

III. Application of Techniques to Characterize Predominant
Nosocomial Pathogens.

10. Staphylococcus aureus (Vanthida Huang).

11. Escherichia coli (Johann D. D. Pitout).

12. Fungal Infections (Jose A. Vazquez).

Index.