Molecular Exercise Physiology

The new edition offers a student-friendly introduction to a history documenting the emergence of molecular biology techniques, methodology, genetics and epigenetics, and the molecular mechanisms that lead to adaptation after exercise, and explicitly links to outcomes in performance, nutrition, physical activity, and clinical exercise.

Auteur

Adam P. Sharples, PhD is a Professor in Molecular Physiology and Epigenetics at the Norwegian School of Sport Sciences (NiH), Olso, Norway. An institute ranked 2nd (out of 300) in the world for sport and exercise sciences. He investigates the underlying cellular, molecular and epigenetic mechanisms of muscle growth (hypertrophy) and wasting (atrophy) using both cell modelling and whole-body approaches. His work first demonstrated human muscle possesses an 'epigenetic memory' of exercise. James P. Morton, PhD is a Professor of Exercise Metabolism at Liverpool John Moores University (LJMU). His research evaluates the impact of nutrient availability on muscle metabolism during exercise and the molecular regulation of skeletal muscle adaptations to exercise training. James has also worked in a number of performance support related roles across both high performance sport and industry working with some of the world's most high profile athletes, sports teams and institutions.

Henning Wackerhage, PhD is a Professor and Molecular Exercise Physiologist. He is specifically interested in the molecular mechanisms by which exercise improves our fitness and health. Particularly the role of the so-called Hippo proteins in skeletal muscle and the association between the proteome, metabolome, athletic performance, disease and aging.

Texte du rabat

Fully revised and expanded, the second edition of Molecular Exercise Physiology offers a student-friendly introduction. It introduces a history documenting the emergence of molecular biology techniques to investigate exercise physiology, the methodology used, exercise genetics and epigenetics, and the molecular mechanisms that lead to adaptation after different types of exercise, and explicitly links to outcomes in sport performance, nutrition, physical activity, and clinical exercise.

Structured around key topics in sport and exercise science and featuring contributions from pioneering scientists, such as Nobel Prize winners, this edition includes new chapters based on cutting-edge research in epigenetics and muscle memory, skeletal muscle stem cells, circadian rhythms, exercise at altitude and in hot and cold climates, circadian rhythms, and exercise in cancer. Every chapter includes learning objectives, structured guides to further reading, review questions, overviews of work by key researchers and box discussions from important pioneers in the field, making it a complete resource for any molecular exercise physiology course. The book includes cell and molecular biology laboratory methods for dissertation and research projects in molecular exercise physiology and muscle physiology.

This book is essential reading for upper-level undergraduate or postgraduate course in cellular and molecular exercise physiology and muscle physiology. It is a valuable resource for any student with an advanced interest in exercise physiology in both sport performance and clinical settings.

Contenu

1. Introduction to Molecular Exercise Physiology

Adam P. Sharples and Henning Wackerhage

2. Methods in Molecular Exercise Physiology * Adam P. Sharples, Daniel C. Turner, Stephen Roth, Robert A. Seaborne, Brendan Egan, Mark Viggars, Jonathan C. Jarvis, Daniel J. Owens, Jatin G. Burniston, Piotr P. Gorski, Claire E. Stewart

• 3. Genetics and Exercise: An Introduction * Claude Bouchard and Henning Wackerhage
• 4. Genetics of Muscle Mass and Strength * Stephen M. Roth and Henning Wackerhage

5. Genetics of Endurance * Stephen M. Roth and Henning Wackerhage

• 6. Epigenetics of Exercise * Daniel C. Turner, Robert A. Seaborne, and Adam P. Sharples
• 7. Signal Transduction and Exercise * Brendan Egan and Adam P. Sharples
• 8. Molecular Adaptation to Resistance Exercise * Keith Baar
• 9. Molecular Adaptations to Endurance Exercise and Skeletal Muscle Fibre Plasticity * Keith Baar

10. Molecular Sport Nutrition Mark Hearris, Nathan Hodson, Javier Gonzalez and James P. Morton

11. Cancer and Exercise * Tormod S. Nilsen, Pernille Hojman, and Henning Wackerhage

• 13. Satellite Cells and Exercise Neil R.W. Martin and Adam P. Sharples