This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis.
The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques.
Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies,currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
Auteur
Dr Kamla Kant Shukla is Assistant Professor of Biochemistry in All India Institute of Medical Science Jodhpur. He passed his Masters in Biochemistry with first division and was awarded Ph.D. in Medical Biochemistry from King George's Medical University, Lucknow in May, 2010. He has worked as Post Doctoral Fellow at Chung Ang University, South Korea and visited Canada, Japan, South Korea and Australia for international scientific interactions and conferences. He has published more than 25 research papers in reputed international journals in area of reproductive and cancer biology and written a book as well and his work has been cited more than 1000 times with an H-index of 18. He has received several International and National awards like Post-doctoral scholar of Kyushu University, Japan and Chung ang University, South Korea. He is an associate editor of Frontier of Genetics and Frontier of Endocrinology. He has delivered various guest lectures in International and National conferences. He is a member of national and International regulatory bodies and several scientific societies.
Dr Sanjeev Misra is the Director and CEO of All India Institute of Medical Sciences, Jodhpur. He passed his MBBS and MS in General Surgery from KGMC, Lucknow, India. He has been a sectional Editor of the Oncology Section of Indian Journal of Surgery and Honorary Secretary (2007-2008), Vice President (2011), President Elect (2012) and President (2013) of the Indian Association of Surgical Oncology. He is a Post Graduate teacher recognized by the MCI and NBE and examiner for M.Ch. and DNB. He is a Fellow of the National Academy of Medical Sciences, India, Fellow of National Academy of Science, India, Fellow of American College of Surgeons, USA and Fellow of International College of Surgeons, USA. He has received several International and National awards like, Commonwealth fellowship and International Guest Scholar of American College of Surgeons. He has been a visiting Professor to King's College, London, Mayo Clinic, Rochester, USA, John Hopkins Medical Center, USA, and University of Pittsburgh Medical Center, USA. For his contribution to surgery he was awarded FRCS, England and Glasgow (Ad eundem). He was awarded fellowships at MSKCC, New York, MD Anderson Cancer Center, Houston and Cancer Institute Hospital, Tokyo. He has published extensively and has over 105 published papers and 20 chapters in several International and National Journals. He is an associate editor of Indian Journal of Surgical Oncology and is on Editorial Board of International Journal of Surgical Oncology. He is a member of the Executive committee of Asian Clinical Oncology Society. He has delivered various guest lectures and orations in International and National conferences. He is the founder member of Indian Breast Group and Indian Liver Group. He has been involved with Medical Education and is dedicated to the teaching, training and practice of surgery and its growth for close to two decades.
Dr Praveen Sharma is Professor and Head of Biochemistry Department, Dean (Research) and Controller of Examination at All India Institute of Medical Sciences, Jodhpur. He has done M.Sc and Ph.D. in (Med) Biochemistry from S.M.S. Medical College, Jaipur, India. He has more than 37 years' experience of teaching Clinical Biochemistry and Laboratory Management. He has more than 100 research publications and 8 book chapters in various prestigious journals and has interest in Diabetes, Metabolic Syndrome, Atherosclerosis, Antioxidants and Lead Toxicity. He has delivered Invited Lectures at various National and International Meetings. He is a recipient of G S Seth Medical College Oration Award (2004), Pattabiraman Oration Award (2010), Awadhesh saran memorial Oration Awards (2013) and A.J. Thakur-ACBI award (2015) for distinguished service and significant contribution to the field of Clinical Biochemistry. He has been awarded with merit award by Rajasthan Government in 2002. He has been twice President of ACBI and Fellow of the Association of Clinical Biochemists of India (FACBI) He is Editor-in-Chief, Indian Journal of Clinical Biochemistry (IJCB) and Chairman, Corporate Wing of ACBI.). He has also served as member of Accreditation Committee of National Accreditation Board for Testing and Calibration Laboratories (NABL) and also NABL Assessor. Dr. Sharma is a Director of National Referral Center of Lead Project India, Jodhpur. He was ACBI Representative to Asia Pacific Federation of Clinical Biochemistry and Laboratory Medicine (APFCB) and International Federation of Clinical Chemistry and Lab Medicine (IFCC). Dr. Sharma is Chair Communication Committee of APFCB and also Chief Editor of APFCB News. Besides he is organizing chairman of forthcoming APFCB Congress 2019 Jaipur.
Contenu
Introduction of molecular diagnostics.- Molecular Diagnostics in Bladder cancer.- Molecular Diagnostics in Lung cancer.- Molecular Diagnostics in Brain cancer.- Molecular Diagnostics in Melanoma.- Molecular Diagnostics in Breast cancer.- Molecular Diagnostics in Non-Hodgkin lymphoma.- Molecular Diagnostics in Cervical cancer.- Molecular Diagnostics in Colorectal cancer.- Molecular Diagnostics in Pancreatic cancer.- Molecular Diagnostics in Oral cancer.- Molecular Diagnostics in Prostate cancer.- Molecular Diagnostics in Kidney cancer.- Molecular Diagnostics in Skin cancer.- Molecular Diagnostics in Leukaemia.- Molecular Diagnostics in Thyroid cancer.- Molecular Diagnostics in Liver cancer.- Molecular Diagnostics in Uterine cancer.- Molecular Diagnostics in Ovarian cancer.- Pharmacogenomics Testing for Medication & Drug Response.