Modulation of Oxidative Stress in Heart Disease

This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease.

The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.

Auteur

Dr Sajal Chakraborti is a Professor of Biochemistry at the University of Kalyani, West Bengal, India. He completed his PhD at Calcutta University, Kolkata, India and his DSc at the University of Kalyani. He also pursued postdoctoral research at Johns Hopkins University, Baltimore; University of Utah, Salt Lake City; and New York Medical College, New York as a Fulbright Fellow. He visited the University of Florida, Gainesville, Florida, where he conducted research on f beta-adrenergic receptor activation in heart disease. His research mainly deals with the role of vasoactive agents in regulating vascular tone under oxidant and calcium signaling phenomena. He has been engaged in biochemistry teaching and research for the past 40 years (email: saj_chakra@rediffmail.com).

Dr Naranjan S Dhalla is a Distinguished Professor at the University of Manitoba, Winnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged in multidisciplinary cardiology research and education for over 50 years. He is currently the Editor-in-chief of Molecular and Cellular Biochemistry (Springer) (email: NSDhalla@sbrc.ca).

Dr Madhu Dixit is a National Chair Fellow of the Translational Health Science and Technology Institute, Faridabad, Haryana, India. She has contributed to the general area of biochemical pharmacology with a special interest in cardiovascular pharmacology and redox biology. Dr Dixit has been engaged in research, especially on drug discovery and development, for over 40 years (email: rmadhudikshit@gmail.com).

Dr Nirmal K Ganguly, a distinguished biotechnologist and former Director General of the Indian Council of Medical Research (ICMR), is associated with Global Health Strategies, New Delhi, India. One important aspect of his research is the understanding of occupational, environmental and nutritional aspects of heart disease. In 2008 he was presented with the Padma Bhushan Award in the field of Medicine by the President of India (email: ganguly1nk@gmail.com).

Contenu
A. Regulation of Oxidative Stress
1. Impact of genetic and epigenetic factors on the oxidative stress in cardiovasculardisease
2. Role of aging and metabolic disease in oxidative stress of heart
3. Role of monoamine oxidases in heart diseases
4. Role of miRNA in oxidative stress induced heart diseases
5. Modulation of Oxidative (stressed) Heart Disease by Uncoupling Proteins
6. Redox regulation in heart by ion channels
7. Molecular regulators in ROS mediated cardiac diseases.
8. The inflammatory stress that follows preceded oxidative stresses in the pathogenesisof heart diseases
9. Metabolic signatures of redox-dependent cardiovascular disease.
10. Role of heat shock proteins in oxidative stress induced heart diseases.
B. Pathophysiology of Oxidative Stress

11. Oxidative stress in metabolic syndrome : experimental model of biomarkers
    12. Oxidative stress as a critical determinant of adult cardiac progenitor cell-fatedecisions
    13. Role of oxidative stress in hyperhomocysteinemia-induced heart disease
    14. Oxidative Stress and the Aging Heart
    15. Basic mechanisms of ischemia/reperfusion injury leading to cellular and tissuedamage
    16. Oxidative stress in congenital heart defects.
    17. Nitrosative stress and cardiogenesis: Cardiac remodeling perturbs embryonicmetabolome
    18. Oxidative Stress and Mitochondrial Dysfunction in Heart Diseases
    19. Role of oxidative stress, mitochondrial dysfunction and autophagy in cardiovasculardisease: Its pathogenesis and amelioration by different small natural molecules
    20. Regulation of cardiac ion channels in stress related heart diseases
    21.In silico perspectives of the mechanism of oxidative stress during the onset of heartdisease.
    22.Biomarkers of oxidative stress and endothelial dysfunction in the elderly: oxidizedLDL versus LDL oxidizability
    C. Prevention & therapeutics
    23. Restoring nitroso-redox balance as a therapeutic for heart disease
    24. Oxidative stress role in cardiovascular prevention and disease
    25. Mitochondrial dynamics and mitophagy in heart: role in disease and interventionalopportunities
    26. Role of exercise in prevention and treatment of heart diseases: focus on redox balance
    27. Mitochondrial biology and its therapeutic use in cardiovascular disease
    28. Oxidative stress-driven cardiotoxicity of cancer drugs.
    29. Modifying redox signaling to enhance success of regenerative therapy in the heart.