MIF Family Cytokines in Innate Immunity and Homeostasis

The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.

Auteur
Richard Bucala, MD PhD; Professor of Medicine, Pathology, and Epidemiology & Public Health at Yale University, School of Medicine, New Haven, CT, USA Jürgen Bernhagen, PhD; Institute of Biochemistry and Molecular Cell Biology, Universitätsklinikum Aachen, RWTH Aachen, Germany

Contenu

MIF and CD74-dependent Mechanisms.- HSP90-stabilized MIF in Oncogenesis and Cell Growth Control- CD74, MIF, and Breast Tumorigenesis: Insights from Recent Large-scale Tumor Genomics and Proteomics Studies.- MIF-dependent Regulation of Monocyte/Macrophage Polarization.- Advances in understanding the role of MIF in the pathogenesis of autoimmune diseases.- Role of MIF in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis.- Role of MIF in Hepatic Inflammatory Diseases and Fibrosis.- MIF and Pulmonary Disease.- MIF Mediates Pelvic Inflammation and Pain.- MIF Family Proteins in Cardiac Ischemia / Reperfusion Injury.- The MIF-CD74 Inflammatory Axis in Alphaviral Infection.- MIF in Eosinophilic Inflammation.- The Role of MIF in Parasitic Infections.- Parasite MIF Orthologs.