Metastasis / Dissemination

This volume emphasizes metastasis/dissemination as im­ nective tissues, muscle, tumours of neuronal origins and portant processes in cancer growth and progression. teratomas. Previous volumes in this series have emphasized aspects of The broad array of neoplastic diseases, multiple target cancer progression, tumor invasion and tumor metastasis sites, and patterns of metastasis and dissemination underlie and the importance of these processes to the pathophysiol­ the importance of achieving crucial insights into particular ogy and morbidity of malignant disease. This volume builds neoplasms. An understanding of metastasis and dissemina­ on these earlier themes and emphasizes metastasis/disse­ tion in man remains an essential objective for the design of mination in man. Following a review of general patterns of new diagnostic and therapeutic strategies for the therapy of metastatic spread in man, metastasis to, or progression of established metastatic disease and spread accompanying neoplasms in several organ systems are highlighted, includ­ site-specific tumor progression. ing: the central nervous system, esophageal cancer, the lung, the large intestine, the liver, bone, epithelial neoplasms, Series Editor Volume Editor endocrine cells, pigmented tissues, supporting tissues, con- Hans E. Kaiser Elizier L. Gorelik VII ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.

Contenu

1. Overview of metastatic spreading.- 2. Pattern of metastasis.- 3. Metastasis to the central nervous system.- 4. Statistics in esophageal cancer progression in man.- 5. Metastatic disease to the lung in the human.- 6. Statistics on lung cancer progression in man.- 7. Progression of cancer of the large intestine.- 8. Liver metastases: Experimental and clinical considerations.- 9. Metastasis to bone in mammals.- 10. Acceleration of metastatic growth after surgical excision of the primary tumor in the experimental animals.- 11. Metastasis of epithelial neoplasms: Progression of neoplasms deriving from lining membranes - A review.- 12. Metastasis of epithelial neoplasms: Desmal epithelia (including vasoformative tissue), epithelia of synovial origin.- 13. Metastases of epithelial neoplasms - Progression of neoplasms deriving from glandular structures: Exocrine glands.- 14. Metastases of epithelial neoplasms: Progression of neoplasms deriving from glandular structures: Endocrine glands - A review.- 15. The normal and abnormal pulmonary neuro endocrine cells.- 16. Progression of neoplasms deriving from pigmented tissues.- 17. Neoplasms metastasis deriving from supporting tissues.- 18. Progression of malignant neoplasms originating directly in connective tissues as such - Mesenchyme, spinocellular, gelatinous, loose, and fibrous connective tissues).- 19. Progression of neoplasms deriving from muscle tissues.- 20. Progression of tumors of the neuronal series.- 21. Tumors of the meninges, neuroglia, choroid plexus and neurohumoral structures.- 22. Metastasis of teratomas.- 23. Psychological influences on metastatic disease progression.- Index of subjects.