Metabolic Inhibitors V3

Metabolic Inhibitors: A Comprehensive Treatise, Volume III reviews developments in metabolic and enzyme inhibition. With contributions by investigators experienced in their respective fields, the book explores metabolic processes or systems and covers topics ranging from membrane transport to immunization; gene activity; DNA, RNA, and protein syntheses; photosynthesis; lipid metabolism; and blood clotting.
Organized into 12 chapters, this volume begins with an overview of transport reactions and their inhibition, emphasizing inhibitors of ATPase including cations, substrates, and products. Some chapters deal with inhibitors, such as antibiotics; polypeptide and protein hormones; modified transfer RNAs; and oligonucleotides. Other chapters discuss inhibitors of immune reactions; animal virus replication; plant viruses and mycoplasma; and isozymes. An account of genetic deletions is also given. Finally, the book considers molecules that act as repressors and derepressors of gene activity.
This book will be beneficial to biochemists and medical research workers, as well as to virologists, microbiologists, plant physiologists, and agronomists.

Contenu

List of Contributors
Preface
Contents of Other Volumes
Dedication
Chapter 1 Inhibition of Transport Reactions
A. Inhibitors of ATPase: NaK-ATPase and Related Enzymic Activities
I. The Relationship of NaK-ATPase to Cation Transport
II. Inhibitory Effects of Cations, Substrates, and Products
III. Inhibitory Effects of CaCl2
IV. Cardioactive Steroid Inhibitors
V. Inhibitory Effects of Erythrophleum Alkaloids
VI. Inhibitory Effects of Sulfhydryl Reagents
VII. Effects of Oligomycin on NaK-ATPase and Related Enzymic Activities
VIII. The Influence of Hydroxylamine on NaK-ATPase
IX. Inhibition by Fluoride
X. Inhibition by Diisopropylfluorophosphate
XI. Inhibition by Berylium Ions
XII. Effects of Neurotropic Agents Including Chlorinated Hydrocarbons
XIII. Effects of Phlorizin, Phloretin, and Diethylstilbestrol
XIV. Effects of Miscellaneous Agents
References
Chapter 2 Inhibition of Transport Reactions
B. Sugars
I. Introduction
II. Classification of Sugar Transport Systems
III. Sugar Transport Inhibitors
References
Chapter 3 Inhibition of Transport Reactions
C. Control of Amino Acid Transfer
I. Introduction
II. Methods of Controlling Amino Acid Transfer
III. Amino Acid Structure
IV. Systems for Amino Acid Transfer
V. Amino Acid Interactions
VI. Sodium and Amino Acid Transfer
VII. Potassium and Amino Acid Transfer
VIII. Calcium and Amino Acid Transfer
IX. Amino Acid Transfer and pH
X. Effects of Other Changes in Environment
XI. Relationship of Amino Acid Transfer to Other Solute Transfer Systems
XII. Control of Amino Acid Accumulation
XIII. Influence of Hormones on Amino Acid Transfer
XIV. Energy Considerations
XV. Amino Acid Transfer and Genetics
References
Chapter 4 Inhibitors of Immune Reactions
I. Introduction
II. Immunosuppressants
III. Variables That Determine the Success of an Immunosuppresive Regimen
IV. Immunosuppressive Mechanisms
V. Human Applications
References
Chapter 5 Repressors and Derepressors of Gene Activity
I. Introduction
II. Prokaryote Transcription
III. RNA Polymerase Control Factors
IV. Eukaryote Transcription
V. Gene Replication
VI. Summary
References
Chapter 6 Inhibitors of RNA and DNA Biosynthesis
I. Introduction
II. Inhibitors of RNA Synthesis
III. Inhibitors of DNA Synthesis
IV. Inhibitors of Both RNA and DNA Synthesis
V. RNA-Dependent DNA Synthesis
References
Chapter 7 Genetic Deletions
I. Introduction
II. Selection and Detection of Mutants Bearing Potential Deletions
III. Operational Criteria for Establishing a Mutation as a Deletion
VI. The Frequency, Topography, and Topology of Deletion Mutations
V. Enzymes That Cut and Repair DNA
VI. Agents That May Promote Deletions
VII. Hypothetical Mechanisms
VIII. Conclusions
References
Chapter 8 Inhibitors of Animal Virus Replication
I. Introduction
II. Compounds Affecting the Early Steps of Virus Replication
III. Compounds Affecting the Late Steps of Virus Replication
IV. Inhibitors of Virus-Specific RNA Synthesis
V. Inhibitors of Virus Protein Synthesis: Cycloheximide, Streptovitacin A, and Puromycin
VI. Inhibitors of Viral DNA Synthesis
References
Chapter 9 Inhibitors of Plant Viruses and Mycoplasma
I. Introduction
II. Substances That Interfere with Establishment of Virus Infection
III. Inhibitors of Virus Increase
IV. Effect of Tetracyclines on Plant-Pathogenic Mycoplasmas
References
Chapter 10 Novel Antibiotics as Metabolic Inhibitors
I. Introduction
II. Inhibitors of Cell Wall Synthesis
III. Interaction of Antibiotics with Lipid Membranes
IV. Inhibitors of the Respiratory Chain and Energy Transfer
V. Inhibitors of DNA Replication and Transcription
VI. Antibiotic Inhibitors of Protein Synthesis
VII. A Potpourri of Antibiotics
VIII. Chemical Structure and Biological Activity of Antibiotics
IX. The Origin and Function of Antibiotics
References
Chapter 11 Polypeptide and Protein Hormones as Inhibitors
I. Introduction
II. Structure and Mode of Action of Protein and Polypeptide Hormones
III. Hormones That Act as Inhibitors
IV. Hormone Analogs as Inhibitors
V. Conclusion
References
Chapter 12 Inhibition of Isozymes
I. Introduction
II. Metabolic Significance of Isozymes and the Role of Inhibitors in Their Study
III. The Role of Inhibitors in Elucidating the Molecular Mechanisms Responsible for the Generation of Isozymes
IV. Inhibition of LDH Isozymes
V. Conclusions
References
Author Index
Subject Index