Metabolic Inhibitors V2

Metabolic Inhibitors: A Comprehensive Treatise, Volume II charts the major advances that have been made in understanding metabolic inhibition and inhibitors. The book explores the inhibition of enzymes, such as catechol amines, acetylcholinesterases, and succinic dehydrogenases, as well as inhibitors of processes ranging from gas transport to photosynthesis, nitrogen fixation, nitrification, and oxidative phosphorylation.
Organized into 23 chapters, this volume begins with a discussion on the biosynthesis of nicotinamide adenine dinucleotide and dinucleotide analogues. The reader is then introduced to the biochemical significance and mode of action of antibiotics; substances interfering with the biogenesis and metabolism of catechol amines; and inhibition of enzyme activities by thioarsenites. Some chapters focus on mercaptide-forming agents, biological alkylating agents, organophosphates, and carbamates, while others examine the metabolic inhibitory effects of quinones, fungicides, and surface active agents. The book also considers the effects of anesthetics, depressants, and tranquilizers on cerebral metabolism, and then concludes with a chapter on inhibition caused by radiation.
This book is a valuable resource for biochemists, advanced students, medical research workers, and research workers in the fields of biological chemistry, microbiology, botany, and agriculture.

Contenu

List of Contributors

Preface

Contents of Volume I

Chapter 16 Dinucleotide Analogues and Related Substances

I. Introduction

II. Biosynthesis of Nicotinamide Adenine Dinucleotide (NAD)

III. Dinucleotide Analogues

References

Chapter 17 Antibiotics

I. Introduction

II. Requirements for Optimum Production

III. Production in Nature

IV. Selectivity of Antibiotics

V. Biochemical Significance of Antibiotics

VI. Mode of Action of Antibiotics; Cellular Effects

VII. Mode of Action of Antibiotics; Biochemical Significance

VIII. Conclusion

References

Chapter 18 Monoamine and Polyamine Analogues

I. General Remarks

II. Amine Analogues

III. Concluding Remarks

References

Chapter 19 Inhibitors of Catechol Amine Metabolism

I. Introduction

II. Substances Interfering with the Biogenesis of Catechol Amines Through Inhibition of Dopa Decarboxylase

III. Substances Interfering with the Metabolism of Catechol Amines

IV. Substances Acting at Receptor or at Storage Sites

References

Chapter 20 Sulfhydryl Agents: Arsenicals

I. Introduction

II. Classification of the Arsenicals

III. Reactions of Arsenicals with Simple Thiols

IV. Enzymes as Thiol Compounds

V. Inhibition of Lipoic Acid-Dependent Reactions

VI. Factors Involved in the Stability of Thioarsenites and their Application to the Inhibition of Enzyme Activities

VII. Effects of Arsenicals on Physiological Activity

VIII. Some Effects of Arsenicals on Tumors

IX. Structure of Arsenicals in Relation to Parasiticidal Activity

References

Chapter 21 Mercaptide-Forming Agents

I. Introduction

II. Metal Cations

III. Organic Mercurials

IV. Two Individual Enzymes

V. Summary

References

Chapter 22 Enzyme Inhibition by Quinones

I. Introduction

II. Quinone Inhibition of Enzymes by Interaction with-SH Groups

III. Quinone Inhibition of Enzymes of Oxidoreduction

References

Chapter 23 Biological Alkylating Agents

I. Introduction

II. Newer Developments

III. Mechanism of Action

IV. Summary and Outlook

References

Chapter 24 Inhibition of Acetylcholinesterase

I. Introduction

II. Theory of Enzymic Hydrolysis

References

Chapter 25 Organophosphates and Carbamates

I. Introduction

II. Carbamates

III. Organophosphates

References

Chapter 26 Herbicides

I. Introduction

II. The Action of Herbicides on the Plant

III. Metabolism of Herbicides by Plants

References

Chapter 27 Fungicides as Metabolic Inhibitors

I. Introduction

II. Inorganic Fungicides

III. Organic Fungicides

IV. Conclusions

References

Chapter 28 Trypanocidal Agents

I. Introduction

II. Summary of Trypanocidal Agents in Current Use

III. Arsenicals

IV. Suramin

V. Aromatic Diamidines

VI. Quaternary Ammonium Trypanocides

VII. Summing up

References

Chapter 29 Cations and Anions: Inhibitions and Interactions in Metabolism and in Enzyme Activity

I. Introduction

II. Physiological Interactions

III. Enzymic Interactions

IV. Conclusion

References

Chapter 30 Polyanionic Inhibitors

I. Introduction

II. Surface Active Agents as Metabolic Inhibitors

III. Inhibition of Enzymes by Organic Mono- or Polysulfonates

IV. Macromolecular Polyanions as Metabolic Inhibitors

V. Summary and Conclusions

References

Chapter 31 Inhibitions in the Citric Acid Cycle

I. Introduction

II. Inhibitors of Succinic Dehydrogenase

III. Fumarate Conversion to L-Malate; Inhibitions of Fumarase

IV. Inhibition of Malate Metabolism

V. Oxalacetate Metabolism

VI. Citrate Breakdown; Inhibition of Aconitase

VII. Metabolism of a-Ketoglutarate

VIII. Isocitrate Oxidation

References

Chapter 32 Uncouplers and Inhibitors of Oxidative Phosphorylation

I. Introduction: Definitions

II. Uncouplers

III. Inhibitors

References

Chapter 33 Effects of Anesthetics, Depressants, and Tranquilizers on Cerebral Metabolism

I. Introduction

II. Anesthetics and Respiration of the Brain In Vitro

III. Anesthetics and Specificity of Oxidative Inhibition

IV. Reversibility of Narcotic Action In Vitro

V. Stimulated Brain Metabolism

VI. Mode of Action of Anesthetics and Allied Substances

VII. Anesthetics and Glycolysis

VIII. Effects of Anesthetics on Biological Acetylations

IX. Steroids

X. Reserpine

References

Chapter 34 Inhibitors of Gas Transport

I. Introduction

II. Poisoning by Carbon Monoxide

III. Methemoglobinemia

IV. Carbon Dioxide Transport

References

Chapter 35 Selective Inhibitors of Photosynthesis

I. Introduction

II. Inhibitors of C02 Assimilation

III. Cyclic and Noncyclic Photophosphorylation

IV. Inhibitors of Oxygen Evolution

V. Inhibitors of Photosynthetic Electron Transport

VI. Inhibitors of ATP Formation

VII. Concluding Remarks

References

Chapter 36 Inhibitors of Nitrogen Fixation

I. Introduction

II. Molecular Gases as Inhibitors

III. Combined Nitrogen Compounds as Inhibitors

IV. Metabolic Inhibitors

V. Retrospect and Prospect

References

Chapter 37 Inhibitors of Nitrification

I. Introduction

II. General Inhibitors of Nitrification

III. Specific Inhibitors of Nitrification

References

Chapter 38 Inhibition Due to Radiation

I. Introduction

II. Effects In Vitro

III. Differences between In Vitro and In Vivo Effects

IV. Inhibitions In Vivo

V. Conclusions

References

Author Index

Subject Index