Metabolic Bone Disease

Metabolic Bone Disease, Volume I covers the approach to a variety of disorders of mineral metabolism. The book discusses bone metabolism and calcium regulation; kidney function in calcium and phosphate metabolism; as well as the role of alkaline phosphatase in metabolic bone disorders. The text also describes the diagnostic value of bone biopsies; the etiology, clinical aspects, therapy, and the main syndromes of vitamin D deficiency, rickets, and osteomalacia; and the pathogenesis and therapy of osteoporosis. The pathogenesis and treatment of nephrolothiasis are also encompassed. Orthopedic doctors, physicians, endocrinologists, and people involved in the research of metabolic bone diseases will find the book invaluable.

Contenu

List of Contributors
Preface
Contents of Other Volumes
1 Bone Metabolism and Calcium Regulation
I. Introduction
II. General Problem of Calcium Regulation
III. General Description of Skeletal Structure and Function
IV. Distribution and Transport of Calcium and Phosphate
V. Regulation of Bone Formation
VI. Regulation of Bone Resorption
VII. Cellular Calcium Regulation
General References
References
2 Kidney Function in Calcium and Phosphate Metabolism
I. Renal Phosphate Transport
II. Renal Calcium Transport
III. Renal Physiology and the Effects of Parathyroid Hormone and Calcitonin on Electrolyte Homeostasis
References
3 Alkaline Phosphatase and Metabolic Bone Disorders
I. Historical
II. Alkaline Phosphatase and Calcification
III. Localization and Purification of Skeletal Alkaline Phosphatase
IV. Tissue Sources of Circulating Alkaline Phosphatases in Normal and Abnormal Subjects
V. Methods of Assay: Normal Values
VI. The Diagnostic Value of Serum Alkaline Phosphatase Determinations in Skeletal Disorders
VII. Alkaline Phosphatase Elevations in Extraskeletal Disorders
VIII. "Stop-Go" Decisions Based on Serum Alkaline Phosphatase
IX. Acid Phosphatase
X. Conclusions
References
4 The Diagnostic Value of Bone Biopsies
I. Introduction
II. Growth
III. Ossification
IV. Remodeling and Turnover
V. Resorption
VI. Reversal Lines
VII. Formation
VIII. Technical Considerations
IX. Skeletal Variability and the Value of Bone Biopsy
X. Quantitative Values in Biopsy Diagnosis
XI. Bone Changes in Metabolic Bone Disease
XII. Appendix
References
5 Vitamin D, Rickets, and Osteomalacia
I. Introduction
II. Vitamin D and Its Metabolism
III. Etiology, Nomenclature, and Clinical Aspects
IV. Radiological and Laboratory Diagnosis
V. Differential Diagnosis
VI. Therapy
VII. Main Diseases and Syndromes Causing Rickets or Osteomalacia
VIII. Conclusion
References
6 Osteoporosis: Pathogenesis and Therapy
I. Definition
II. Physiological Osteopenia
III. Diagnostic Aids
IV. Classification
References
7 Nephrolithiasis
I. Introduction
II. Types of Stones Found in the Urinary Tract
III. Stone Formation and Growth
IV. Pathogenesis of Recurrent Stone Disease
V. Specific Disease of Bone Associated with Nephrolithiasis
VI. Treatment of Renal Stone Disease
References
Index