Marine Bioactive Molecules for Biomedical and Pharmacotherapeutic Applications

This book explores cutting-edge research on the discovery and application of marine bioactive molecules for biomedical and pharmacotherapeutic purposes. The book begins by delving into the bioprospection of marine sponge microbiomes for bioactive metabolites using advanced metagenomics tools. It then explores metagenome mining approaches for the discovery of marine microbial natural products. The use of marine-derived fungi as a source of anticancer secondary metabolites is also discussed. The book then turns to the biomedical applications of marine-derived biomaterials, including marine biopolymers in tissue engineering and regenerative medicine. Marine-derived pharmaceuticals and polymeric nanostructures for cancer treatment are also examined. Next, the book looks at the use of marine microbial sources for the synthesis of metallic nanomaterials, prospects, current development, and challenges in nanomedicine. The book continues by exploring the treasure trove of natural polymers fortissue engineering in the marine environment. It also discusses the immunomodulatory and therapeutic potential of marine-derived astaxanthin, current developments, and prospects. Finally, the book concludes by exploring the recent progress in marine-derived nutraceuticals and marine phytoplankton bioactive compounds and their applications in medicine.

Auteur

Dr. Pallaval Veera Bramhachari is currently an associate professor in the Department of Biosciences & Biotechnology at Krishna University, Machilipatnam, A.P State, India. He has earlier served as a postdoctoral research scientist at the Bacterial Pathogenesis Laboratory, Queensland Institute of Medical Research (QIMR-Berghofoer Research Center), Brisbane, Queensland, Australia, and a DBT postdoctoral research fellow at the Department of Microbiology and Cell Biology (MCBL), Indian Institute of Science (IISc), Bangalore. He completed his Ph.D. in microbiology from Goa University, India. His major research interests are the investigations in the areas of applied research in microbiology and molecular cell biology viz. exploring the biochemical mechanism of bacterial-biofilm formations, extracellular microbial polysaccharides (EPS), extracellular proteins (ECP) and the structure-function relationship of bacterial EPS, ECPs, biosurfactants (glycolipids and rhamnolipids), pathogenic and virulence characteristics of bacteria. He has published more than 150 research articles in Scopus-indexed journals, authored and co-authored 9 international books. He has served as a reviewer and editorial board for several International journals. He is a member of numerous scientific societies and organizations, like Indian Science Congress, Society of Biological Chemists, AMI & SBTI, India. He completed two major research projects from DST-SERB & DST-NRDMS, Govt of India. He was conferred with various prestigious awards, notably, the Science Education Research Board (SERB), Government of India-Young Scientist award (2011) with a research project and Nominated as associate fellow of Andhra Pradesh Academy of Sciences (APAS)-2016, MASTER TRAINER: Andhra Pradesh English Communications Skills Project. British Council & APSCHE 2017, Andhra Pradesh State Best Scientist award-2017, Dr. V. Ramalingaswamy Memorial award for Biomedical Sciences-2019, KAPL Award (Industrial Biotechnology)-SBTI Annual awards -2022, Dr.A.P.J. Abdul Kalam Teacher Excellence Award-2022. He also obtained two Indian patents. He has more than 18 years of teaching and research experience in Molecular Microbiology, Virology and Immunology, IPR, Bioprocess engineering, and Microbial and Environmental Biotechnology at the university level. Dr. Chanda Vikrant Berde is currently an assistant professor in the Marine Microbiology program of School of Earth, Ocean and Atmospheric Sciences, Goa University, Goa, India. She has earlier served as an assistant professor in the post graduate programs of Departments of Microbiology and Biotechnology at Gogate Jogalekar College, Ratnagiri, Maharashtra, India (2010-2020); Scientist (Microbiology) at Vidya Pratishthan's School of Biotechnology, Baramati, Maharashtra, India (2005-2010) as well as assistant professor, Department of Biotechnology, Dhempe College of Arts and Science, Goa, India (2004-2005). She has completed herdoctoral and post-doctoral studies from the Department of Microbiology, Goa University, Goa. She has more than 18 years of teaching experience in general microbiology, genetic engineering, biochemistry, bioprocess and biotechnology, IPR, archaea, extremophilic microbiology, estuarine microbiology, nanobiotechnology, etc. Her research experience is over 20 years and the areas of her research interests are bioactive biomolecules, endophytic microorganisms, PGPR, microbial metabolites of industrial importance, microbial remediation, media formulations. She has guided more than 80 master's research projects in subjects of Microbiology, Biotechnology and Marine Microbiology. She is a recognized guide for Ph.D. in Marine Microbiology at Goa University with more than 50 research articles published in peer-reviewed national and international journals and authorship or co-authorship of numerous book chapters. She is editor of 3 books by reputed publishers. She has completed 2 research projectsfunded by DBT, Govt. of India and the University of Mumbai, to her credit. She is a member of many scientific societies and organizations importantly, Mangrove Society of India, Microbiologists Society, India and Society for Environment and Biodiversity Conservation, Ratnagiri. She has actively participated in social awareness programs like mangrove conservation and plantation, covid-19 awareness, AIDS awareness, tree plantations