Studies on Arthritis and Joint Disorders

Joint diseases are a major public health concern. Reactive oxygen species are mediators in pathways associated with joint tissue injury. Oxidative Stress in Applied Basic Research and Clinical Practice: Studies on Arthritis and Joint Disorders provides background to understanding the role of reactive oxygen species in joint diseases, as well as therapeutic strategies for their regulation. International experts discuss recent advances on experimental and clinical data focused on free radical-mediated mechanisms of disease. The book also addresses the protective role of antioxidants against the insult of reactive oxygen species in rheumatic diseases.

Auteur

María José Alcaraz, Ph.D., is a full Professor in Pharmacology at the Department of Pharmacology, University of Valencia, Spain, and former Head of this Department. After completing her Ph.D. at the University of Valencia with Extraordinary Award, she undertook postdoctoral research funded by the Spanish Ministery of Education at the Department of Pharmacology, King's Col. London (1983-1984). She also worked as a visiting researcher at the Unité 348 INSERM, Paris (1998) and received the Dr. Esteve Foundation Award to the best publication in pharmacology and Almirall Award to the best project in pharmacology. In addition to act as editor or referee for several international journals and expert for scientific projects evaluation in different countries and international organizations, she has played an active role in international cooperation with Latin America. Maria José Alcaraz is the head of the Pharmacology of Inflammation group, Department of Pharmacology, University of Valencia, Spain, which focuses on the pathogenesis of the inflammatory process, oxidative stress regulation and the development of new therapeutic targets for the treatment of joint diseases mainly rheumatoid arthritis and osteoarthritis.

Dr. Oreste Gualillo obtained his PhD in Pharmacology at the Department of Experimental Pharmacology of the University Federico II, Naples (Italy). He received training in molecular endocrinology under Prof. Paul A. Kelly at the Necker School of Medicine, Paris. In 1998 he moved to the Laboratory of Molecular Endocrinology of the University of Santiago de Compostela, Spain, where he worked as a Marie Curie postdoctoral research fellow. In 2001 he set up his own research group at the Santiago University Clinical Hospital. He is currently a Class A Stable researcher with the SERGAS (Servizo Galegode Saude) and Carlos III Health Institute of the Spanish Ministry of Health, heading the NEIRID (NeuroEndocrine Interactions in Rheumatologyand Inflammatory Diseases) research laboratory of the Santiago University Clinical Hospital at the IDIS (Instituto de Investigación Sanitaria) of Santiago de Compostela. He has published over 80 papers and in the last years his research was focussed on defining the multifaceted role of adipokines in chondrocyte pathophysiology.

Olga Sánchez-Pernaute, MD, PhD, is a senior rheumatologist in the Jimenez Diaz Foundation University Hospital and assistant Prof at the Autonoma University School of Medicine in Madrid. She has a dilated background in translational research, focused on the study of innate mechanisms of disease associated to autoimmune rheumatic conditions. Of note are her early contributions to the field of inflammatory mediators in experimental models of arthritis, and the pioneer work on the role of fibrin in the progression of synovitis. She was invited for a one-year fellowship at the Laboratory of Experimental Rheumatology of Zürich University, where she developed her research interest in epigenetics. In the last few years she has created a Multidisciplinary Unit for Systemic Autoimmune Diseases that she currently directs at her Institution.

Résumé
This next volume in our established series proposes to systematically review the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as oxidative stress, in the pathology of arthritis and other joint diseases. It will describe the most current diagnostic tools , laboratory methods and technology, to suggest ways of prevention and treatment and to emphasize the concept of the bench-to-bedside approach. The book will also provide specific coverage on emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents and several more relevant aspects. In addition, the book will promote the concept of using biomarkers representative of oxidative stress reactions and free radical damage , as well as describe the effect of antioxidants in treating disease in clinical trials. The content will be valuable to researchers studying the development of arthritis/joint disease, and clinicians treating patients with these diagnoses.

Contenu
Biomarkers of oxidative stress in joint diseases.- Regulation of T-cell functions by oxidative stress.- Nitric oxide and the respiratory chain in synovial cells and chondrocytes.- Adipokines, molecular players at the crossroad between inflammation and oxidative stress. Role in arthropathies.- Regulation of cartilage and bone metabolism by oxidative stress.- Role of oxidative stress in bone aging.- Genetic Component of Oxidative Stress in Rheumatoid Arthritis.- Oxidative stress in rheumatoid arthritis.- Oxidative stress and premature atherosclerosis in RA.- Role of Oxidative Stress and Reactive Oxygen Radicals in the Pathogenesis of Systemic Sclerosis.- Antioxidant and anti-inflammatory properties of heme oxygenase-1 in osteoarthritic articular cells.- Oxidative stress at the crossroads between osteoarthritis and metabolic syndrome.- Metabolic syndrome and gout.- Natural Antioxidants in the pharmacological treatment of rheumatic immune and inflammatory diseases.- Antioxidants inthe treatment of osteoarthritis and bone mineral loss.- Anti-cytokine agents to combat oxidative stress.- Oxidative Conditioning and treatment for Osteoarthritis.- The role of sirtuins in arthritis.- MicroRNA molecules, master regulators, biomarkers and potential therapies.- Estrogen-dependent transcriptional activity, a protection against ROS in osteoarthritis.