Lipotropin and Related Peptides

Hormonal Proteins and Peptides, Volume V: Lipotropin and Related Peptides deals with peptides that have neurobiological properties.

This book consists of five chapters. Chapter 1 reviews the chemistry of melanotropins, while Chapter 2 describes the most potent morphinelike peptide, ?-endorphin. The third chapter summarizes the chemistry and biology of lipotropins that were discovered and characterized from 1964 to 1965. Chapter 4 examines the properties and physiological role of neurophysins. A historical perspective of the achievements of the Uppsala School regarding the separation methods and biographical sketch of Arne Tiselius are presented at the last chapter.

This book is recommended for endocirnologists, clinicians, and students researching on lipotropins.

Contenu

List of Contributors

Preface

Contents of Previous Volumes

1. The Chemistry of Melanotropins

   I. Introduction

   II. Preparation of Melanotropin Concentrate and Isolation of Porcine ß-MSH

   III. Isolation of a- and ß-Melanotropins from Camel Pituitary Glands

   IV. Structure and Synthesis of a-Melanotropin

   V. Synthetic Peptides Related to a-Melanotropin

   VI. Structure and Synthesis of ß-Melanotropins

   VII. Structure-Activity Relationships of ß-MSH by Synthetic Approach

   VIII. Dogfish Melanotropins

   IX. Various Studies on ß-Melanotropin

   X. Inactivation and Activation

   XI. Concluding Remarks

   References

2. ß-Endorphin: A New Biologically Active Peptide from Pituitary Glands

   I. Introduction

   II. Isolation of ß-Endorphin

   III. Primary Structure

   IV. Synthesis

   V. Morphinelike Activity

   VI. Development of Tolerance and Physical Dependence

   VII. Cross-Tolerance to Morphine

   VIII. Experiments in the Cat

   IX. Behavioral Activity in Rats

   X. Structure-Activity Relationships

   XI. Synthesis and Biologic Activity of ß-Endorphin Analogs with D-Amino Acids in Residue Positions 1, 2, 4, and 5

   XII. Synthesis and Biologic Activity of ß-Endorphin Analogs with Shortened Peptide Chains

   XIII. Extraanalgesic Activity

   XIV. Radioimmunoassay: Dissociation of Opiate Activity and Immunoreactivity

   XV. Concluding Remarks

   References

3. Lipotropins

   I. Introduction

   II. Purification

   III. Structure Studies

   IV. ß-MSH Precursor Hypothesis

   V. In Vitro Biosynthesis

   VI. Pituitary Cells Producing ß-LPH

   VII. Radioimmunoassay

   VIII. Biologic Activities of Lipotropins

   IX. Mechanism of Action of ß-LPH at the Cellular Level

   X. Physicochemical Studies of Sheep ß-LPH

   XI. Summary and Conclusions

   XII. Addendum

   References

4. The Neurophysins

   I. The Discovery of the Neurophysins

   II. Properties of the Neurophysins

   III. Isolation and Composition of Neurophysins

   IV. Structure of Neurophysins

   V. Relationship of Hormones and Neurophysins

   VI. Interaction of the Neurophysins with the Neurohypophyseal Hormones

   VII. Measurement of Neurophysins

   VIII. Does Neurophysin Have a Systemic Biologic Role?

   IX. Speculations on the Evolution of Neurophysin

   References

5. Separation Methods and Arne Tiselius

   Text

   References

Author Index

Subject Index