Lipid Metabolism

Lipid Metabolism focuses on the regulation and metabolism of lipids. This book is composed of 10 chapters that specifically deal with fatty acids, prostaglandins, glycerides, glycerophosphates, cholesterol, isoprenoids, and aromatic compounds.
This text starts with an overview of fatty acid metabolism and its controlling factors. This topic is followed by discussions on the physiochemical aspects of oxidative metabolism of fatty acids, with a special emphasis on the role of carnitine in this process. A chapter highlights the several important aspects of higher plant lipid metabolism. Other chapters are devoted to the structures, biosynthesis, and metabolism of prostaglandins, bacterial lipids, phospholipids, glycerides, and steroids. The final chapters describe the biogenesis of aromatic substances through the polyketide path, including polyisoprenoid quinines and related compounds.

Contenu

List of Contributors

Preface

I. Fatty Acid Metabolism

I. Introduction

II. Fatty Acid Oxidation

III. Fatty Acid Biosynthesis

IV. Elongation of Fatty Acids

V. Desaturation of Fatty Acids

VI. a-Oxidation of Fatty Acids

VII. -Oxidation of Fatty Acids

VIII. Ketone Body Formation

IX. The Control of Fatty Acid Biosynthesis

X. The Control of Fatty Acid Oxidation

References

II. Physiological-Chemical Aspects of Fatty Acid Oxidation

I. Introduction

II. Carnitine

III. The Role of Carnitine in Long-Chain Fatty Acid Oxidation

IV. Mitochondrial Compartmentation

VI. Carnitine Acetyltransferase

VII. Gluconeogenesis

VIII. Ketogenesis

IX. Fatty Acid Oxidation and Glucose Homeostatis

X. Carnitine Depletion States

References

III. Fatty Acid Metabolism in Plants

I. Introduction

II. Oxidative Systems

III. Biosynthesis

IV. Unsaturation

V. Waxes

References

IV. Structures, Biosynthesis, and Metabolism of Prostaglandins

I. Chemistry of Prostaglandins

II. Biosynthesis of Prostaglandins

III. Metabolism of Prostaglandins

References

V. Bacterial Lipids

I. Introduction

II. The Apolar Substituents of the Bacterial Lipids

III. Glycolipids

IV. Phospholipids

V. The Role of Lipids in Bacterial Cell Membranes

References

VI. Phospholipid Metabolism

I. Introduction

II. Specific Metabolic Processes

III. General Metabolic Studies

References

VII. Glyceride Metabolism

I. Structural Considerations

II. Lipases

III. Biosynthesis of Triglycerides

IV. Metabolism of Glyceryl Ethers and Glycosyl Diglycerides

V. Absorption of Glycerides

VI. Transport of Chylomicrons and Their Uptake by Tissues

References

VIII. Steroid Metabolism

I. Cholesterol Biosynthesis

II. Transformations of Cholesterol

References

IX. The Biogenesis of Aromatic Substances

I. Introduction

II. The Reactions of Aromatic Ring Biosynthesis

III. Miscellaneous Biogeneses

IV. Conclusion

References

X. Biosynthesis of Polyisoprenoid Quinones and Related Compounds

I. Introduction

II. Ubiquinone and Related Compounds

III. Ubichromenols

IV. Quinones Derived from Terpenoids

V. Other Isoprenoid Quinones of the Benzoquinone Type

VI. Phylloquinone, Menaquinones, and Related Compounds

VII. Anthraquinone Biosynthesis

References

Author Index

Subject Index