Leukocyte Membrane Determinants Regulating Immune Reactivity

Leukocyte Membrane Determinants Regulating Immune Reactivity is a result of the Leukocyte Culture Conference meeting held at Amsterdam in 1975. Abstracts presented in the meeting are compiled in this book. The topics of these abstracts are all under leukocyte biology and include not just lymphocytes but also monocytes, macrophages, and granulocytes.
The text is composed of six major sections. The first section features abstracts that deal with ligand binding and subsequent changes in membrane. Section II focuses on the receptors on lymphocytes in the context of various subpopulations. Immune reactivity, specifically its augmentation or suppression, is the main topic of Section III. Gene products are emphasized in Section IV, while effector functions of membrane determinants are tackled in Section V. Finally, Section VI features leukocyte membrane determinants in differentiation and maturation.
The book presents much detailed information that will be of great help to students or professionals in the study of biology, specifically leukocyte biology.

Contenu

Preface

Acknowledgments

Section I. Ligand Binding and Subsequent Changes in Membrane Properties

Control of the Lateral Mobility of Membrane Proteins

Modulation of Lymphocyte Mitogenesis

Reversible Modifications of Cell Membrane Structures Induced by Antibodies against Transplantation Antigens of Man

Interaction of Non-Mitogenic and Mitogenic Lectins with T Lymphocytes. Association of Cellular Receptor Sites

Dynamic Behaviour of Concanavalin Receptor Sites on Rat Lymphocytes

Mechanisms of Lymphocyte Activation. II. Negative Cooperativity in the Binding of Phytohemagglutinin (PHA) to Its Lymphocyte Receptors

The Role of Some Membrane-Related Events in B Lymphocyte Activation by Antigen

Dissociation of Mitogenic and Immunogenic Activities of DNP-Levan Conjugates for B Cells in Mice

Lymphocyte Triggering by Bacterial LPS. Dissociation between Immunogenicity of TNP-LPS and Mitogenic and Complement Activating Properties

Inhibition of LPS Mitogenicity by Polymyxin B Results in Loss of Immunogenicity of Hapten-LPS Conjugates

Differential Inhibitory Effects of Chlorpromazine on the Responses of Lymphocytes to Mitogens and Allogeneic Cells

Properties of Thymocyte Membrane Areas Bearing Concanavalin A Receptors of High Affinity

Interaction of Lectins with Human Lymphocytes Studied by a Surface-Labeling Technique

The Fate of IgM and of Anti IgM on Antibody-Coated Daudi Cells

Antibody Induced Changes in the Expression of Membranal Receptors and Antigen Receptors in Lymphocytes

Differential Effects of a Mushroom Lectin (AbL) on Parameters of Lymphocyte Activation

Differential Agglutination of Murine Lymphoid Cells by an Invertebrate Lectin (LAgl)

Modulation of Interaction of WGA with Membrane Receptor Sites by a Membrane Mobility Agent and by Trypsin

Inhibition of Lymphocyte Mitogenesis by Immobilized Antigen-Antibody Complexes

Prolongation of Mitogenic Capacity of Periodate Treated Lymphocytes by Exposure to Glutaraldehyde

Cytoplasmic Cooperation Induced between Mitogen Stimulated Immune Cells

Potentiation of Cyclic AMP (cAMP) Generation in Leukocytes by Combination of Concanavalin A (Con A) with Prostaglandins (PG)

Ion Distribution Patterns in Human Lymphocytes: The Effects of Concanavalin A and Ouabain

Calcium Ionophore A23187 and Lymphocyte Activation

The Role of Divalent Cations in the Initiation of Lymphocyte Activation

Section II. (Antigen) Receptors on Lymphocytes of Different Subpopulations

Characteristics of Idiotype-Positive T Lymphocytes and the Use of Anti-Idiotypic Antibodies to Selectively Inhibit T Cell Function

Idiotypic Identity of Strep. A. Specific Antigen Recognition Sites on Mouse T and B-Lymphocytes

Shedding of T Lymphocyte Receptors for Alloantigens

Functional Studies of Lymphoid Cells Defined and Isolated by a Fluorescence Activated Cell Sorter (FACS) from Normal and Athymic Mice

Density of Surface Ig on B-Cells: Ontogenic Studies of a Population of Splenic B-Cells in Normal Mice and Mice with an X-Linked B-Lymphocyte Immune Defect

Selective Recruitment In Vivo of Subsets of Recirculating Lymphocytes Reactive to H2 Determinants

Cell Surface Immunoglobulin of Mouse T Lymphoma Cells and Cultured Fetal Thymocytes

Studies on the Expression of Cell Surface Determinants on Activated Mouse Lymphocytes

Origin and Specificity of Surface Immunoglobulin on MLR Activated Mouse T Cells

Active and Passive Thyroglobulin-Rosette Forming Cells in Obese Strain (OS) Chickens with Spontaneous Autoimmune Thyroiditis

Antigen-Binding Lymphocytes in Mice with an X-Linked B-Lymphocyte Defect

Evaluation of Polyclonal B Cell Activators (PBA) with Chromosomally Marked Cell Populations

Quantitative Analysis of Cellular and Humoral Immunoglobulin in Bursectomized Chickens

The Presence of IgG Affinity on Human Lymphocytes Bearing Both Complement and SRBC Receptors

Studies on the Fc Receptor of Human Peripheral Blood Monocytes and Peritoneal Macrophages: Possible Evidence for Inducibility

Behavior and Fine Structure of Human Fc Receptor-Bearing Lymphocytes Adherent to Immobilized Antigen-Antibody Complexes

Regeneration of Antigen-Binding Receptors on B Lymphocytes

Kinetic Studies of T and B Lymphocyte Membrane Markers in Mitogen Induced Proliferation

Isolation and Characterization of Phytohemagglutinin-Responsive, Concanavalin A-Nonresponsive Human T Lymphocytes

Murine T-Cell Lymphomas, a Model System for Mouse T Cells

Human Lymphocyte Subpopulations

Section III. Augmentation versus Suppression of Immune Reactivity Controlled by Leukocyte Membrane Determinants

Cell Cooperation Mediated by Products of Genes in the Major Histocompatibility Complex

Control of Immunocompetent Cell Differentiation and Function by Products of the Major Histocompatibility Gene Complex

A Soluble Suppressor of T Cell Response In Vitro: Characterization and Genetic Restriction of Activity

Suppression of Immunoglobulin Synthesis in Vitro by Purified Antibody to IgD

No Histocompatibility Requirements for Macrophage-Lymphocyte Interactions in the Primary Immune Antibody Response to Sheep Erythrocytes In Vitro

Characterization of Macrophage Derived Factors Effective in T-Helper Cell Induction

Dissection of the Role of Accessory Cells in Phytohemagglutinin-Induced T Lymphocyte Proliferation

Suppression of In Vitro Antibody Synthesis by a T Cell Product. Its Relation with the Fc Receptor of Activated T Cells

Amplification or Controlling Genes in Cell Mediated Lympholysis

Interaction of C-Reactive Protein (CRP) with Lymphocytes and Monocytes: Complement Dependent Opsonic Adherence and Phagocytosis

Cell Activation Due to an 'M' Locus Product on Murine B Cells in a GVH Model without Killer Cell Generation

Tropism of Surface Immunoglobulins May Help Determine Isogeneic and Allogeneic Lymphocyte Interactions

In Vitro Generation of Suppressor Cell Activity Suppression of in Vitro CML Induction

Demonstration of Human Culture PFC (HcPFC) and Suppressor Lymphocytes in Congenital Agammaglobulinemia (A ) and Common Variable Dysgammaglobulinemia (DYS )

In Vitro Studies on the Cellular Basis of the Unresponsiveness in Mice to (TG)AL

Macrophage Mediated Inhibition of Lymphocyte Blastogenesis

Absolute Macrophage Requirement for T-Lymphocyte Activation by Mitogens

Section IV. Gene Products of the Major Histocompatibility Complex in the Immune Response

Cellular Expression of Ia Antigens and Their Possible Role in Immune Reactions

Murine Ia Antigens. Expression on T and B Cells and Their Role in Immune Response

Structural Characteris…