Lesions and Transplantation

Methods in Neurosciences, Volume 7: Lesions and Transplantation describes the chemical and nonchemical production of lesions and preparation and development of transplants, implants, and grafts.
This book consists of four sections-chemical and nonchemical lesioning; model systems utilizing lesioning; transplants, implants, and grafts; and assessment of lesions and transplants.
In these sections, this volume discusses the excitotoxins as tools for producing brain lesions; use of acromelic acid for production of rat spinal lesions; and opioid and nonopioid antinociception as revealed by lesion studies. The endothelin-1-induced lesions in the brain as a new model of focal ischemia; fetal implants in the lesioned spinal cord of the rat; and hippocampal transplants in oculo are also elaborated. This book likewise covers the assessment of neurochemical function of brain transplants and in vitro electrophysiological analysis of in oculo.
This publication is intended for neuroscientists, but is also beneficial to researchers conducting work on lesions and transplants.

Contenu

Contributors to Volume 7
Preface
Volumes in Series
Section I Chemical and Nonchemical Lesioning

1. Lesioning of Rat Nigrostriatal Dopamine Pathway with 1-Methyl-4-phenylpyridinium Ion (MPP+)
2. Exeitotoxins as Tools for Producing Brain Lesions
3. Excitotoxin-Lesioned Rat Striatum
4. Use of Acromelic Acid for Production of Rat Spinal Lesions
5. Use of Ibotenic Acid to Selectively Lesion Brain Structures
6. Monosodium Glutamate (MSG) Lesions
7. Comparison of Electrolytic and Radio-Frequency Lesion Methods
8. Use of Cold to Reversibly Suppress Local Brain Function in Behaving Animals
9. Chorioretinal Photocoagulation by Different Laser Sources
10. Production of Reversible Local Blockage of Neuronal Function
11. Lesioning the Nucleus Basalis
    Section II Model Systems Utilizing Lesioning
12. Unilateral MPTP-Lesioned Monkey as an Animal Model for Parkinson's Disease
13. MPTP-Induced Parkinsonism in Nonhuman Primates
14. Alteration of Hippocampal RNA Prevalence in Response to Deafferentation
15. Opioid and Nonopioid Antinociception as Revealed by Lesion Studies
16. Neurochemical Lesioning Techniques for Assessing Regulation of Monoamine Receptors
17. Influence of 7V-Methylaspartic Acid Lesions in Adult Mice on Estrous Cyclicity and Related Neuroendocrine Parameters
18. Endothelin-1 -Induced Lesions in the Brain as a New Model of Focal Ischemia
    Section III Transplants, Implants, and Grafts
19. Fetal Hypothalamic Brain Transplantation to Ventromedial Hypothalamic Obese Rats
20. Fetal Implants in the Lesioned Spinal Cord of the Rat
21. Preparation and Intracerebral Grafting of Dissociated Fetal Brain Tissue in Rats
22. Hippocampal Transplants in Oculo: A Model for Establishment of Isolated Circuits
23. Lesion and Transplantation in Rat Hippocampal Formation: Measurement of Electroresponsiveness and Reestablishment of Circuitries
24. Transplantation of Human Sympathetic Neurons and Adrenal Chromaffin Cells into Parkinsonian Monkeys
25. Shiverer and Other Marker Models Used in Intracerebral Transplantations of Glial Cells
    Section IV Assessment of Lesions and Transplants
26. Assessment of Neurochemical Function of Brain Transplants
27. Magnetic Resonance Imaging of Rat Brain to Assess Kainic Acid-Induced Lesions and Transplants
28. Use of Positron Emission Tomography to Assess Effects of Brain Lesions in Experimental Subhuman Primates
29. In Vitro Electrophysiological Analysis of in Oculo Transplants
30. Regulation and Assessment of Receptors Following Transplants
    Index