Organometallic Compounds and Living Organisms

Organometallic Compounds and Living Organisms provides information pertinent to the fundamental aspects of organometallic compounds and living organisms. This book discusses the biological effects of organometallic compounds.

Organized into 10 chapters, this book begins with an overview of the recognition of methylmercuric compounds as the causative agents of Minamata disease, which has generated intensive research of their toxic effects. This text then examines the number of investigative applications of the biological inertness of silicones. Other chapters consider the capacity of many organometals to deactivate enzymes, which makes these compounds very useful for studying the nature of the enzyme active site. This book discusses as well the use and preparation of organometallurium compounds as imaging agents. The final chapter deals with the formation and cleavage of metal(loid)-carbon bonds, which play significant roles in the environmental transformation and circulation of metal(loids).

This book is a valuable resource for chemists.

Contenu

Preface

1. Historical Aspects
   I. Some Basic Concepts
   II. Early Chemotherapeutic Uses
   III. Early Work in Organometal Toxicology
   References
2. Medicinal and Pharmaceutical Applications
   I. Introduction
   II. Organometallic Compounds as Antibiotics
   III. Therapeutic Applications
   IV. Silicones as Prosthetic Agents
   References
3. Toxicology of Organometallic Compounds
   I. Introduction
   II. Quantitative Toxicity Studies
   III. Mechanisms of Toxicity
   IV. Antidotes to Organometal Poisoning
   References
4. Applications to Biochemical Investigations
   I. Introduction
   II. Chemical Investigations
   III. Biological Investigations
   References
5. Organometallic Compounds and Microorganisms
   I. Introduction
   II. Toxicological Investigations
   III. Bacterial Metabolism of Organometals
   IV. Other Microorganisms
   References
6. Organometallic Compounds and Fungi and Algae
   I. Introduction
   II. Toxicological Investigations
   III. Fungicidal Organometals in Agriculture
   IV. Organometals as Surface Protectants
   V. Investigations on Fungicidal Organometals
   References
7. Organometallic Compounds and Plants
   I. Introduction
   II. Plant Growth Regulators
   III. Weed Control Agents
   IV. Investigations on the Interactions of Organometals with Plants
   References
8. Organometallic Compounds and Animals
   I. Introduction
   II. Land Invertebrates
   III. Aquatic Invertebrates
   IV. Vertebrates
   References
9. Biological Alterations of Metal-Carbon Bonds
   I. Introduction
   II. Biological Methylation
   III. Biological Alkylation
   IV. Biological Cleavage of Metal-Carbon Bonds
   V. Enzymatic Hydroxylation of Organometallic Compounds
   References
10. Organometallic Compounds in the Environment
    I. Introduction
    II. Environmental Transformations of Organometals
    III. Biological Transport of Organometals
    IV. Environmental Cycles Involving Organometals
    References
    Index to Chemical Substances
    Index to Organisms
    Subject Index