Human Developmental Toxicants

Human Developmental Toxicants offers up-to-date and concise information on the chemical structures, properties, and biological activities for 50 known agents that adversely affect prenatal and postnatal human development. Focusing on one compound per chapter, the book also includes associated biological data from animals for each agent. An accompanying CD summarizes all of the data discussed in the text within an electronic database. The CD also contains three-dimensional structure representations and 49 calculated physicochemical and topological parameters of each toxicant, useful for building structure activity relationship (SAR) models linking the chemical properties with observed human developmental toxicity.

Auteur

James L. Schardein

Orest T. Macina

Contenu

Aminopterin. Busulfan. Cyclophosphamide. Methotrexate. Chlorambucil. Mechlorethamine. Cytarabine. Tretinoin. Propranolol. Penicillamine. Vitamin A. Carbamazepine. Danazol. Paramethadione. Carbon Monoxide. Formaldehyde. Isotretinoin. Captopril. Misoprostol. Streptomycin. Methimazole. Ethylene Oxide. Tetracycline. Caffeine. Thalidomide. Primidone. Fluconazole. Ergotamine. Propylthiouracil. Medroxyprogesterone. Cocaine. Quinine. Methylene Blue. Warfarin. Phenobarbital. Trimethoprim. Methyltestosterone. Disulfiram. Valproic Acid. Carbon Disulfide. Norethindrone. Phenytoin. Etretinate. Toluene. Ethisterone. Acitretin. Valsartan. Diethylstilbestrol. Pseudoephedrine. Ethanol. Summary and Conclusions.