Isozymes V2

Isozymes, II: Physiological Function contains manuscripts presented at the Third International Conference on isozymes convened in April 1974 at Yale University.
Separating 53 manuscripts into chapters, this book first discusses the medical uses of isozymes. It then describes the various dehydrogenase isozymes mechanisms of action and biological functions. Other general topics explored are the roles of isozymes in adaptation to varying temperatures and their use in the study of mitochondria. Significant topics on specific isozymes are given separately in other chapters.

Contenu

Organizing Committee

List of Contributors

Preface

Acknowledgments

Medical Uses of Isozymes

Mechanisms of Action and Biological Functions of Various Dehydrogenase Isozymes

Use of Affinity Chromatography for Purification of Lactate Dehydrogenase and for Assessing the Homology and Function of the A and B Subunits

Effect of Environment on Kinetic Characteristics of Chicken Lactate Dehydrogenase Isozymes

Lactate Dehydrogenase from Liver, Morris Hepatomas, and HTC Cells

Hereditary Deficiency of Subunit B of Lactate Dehydrogenase

The Properties of Purified LDH-C4 from Human Testis

Autoantigenicity of LDH-X Isozymes

Relationship between the Change in the Tertiary Structure of Human Tumor Lactate Dehydrogenase and Carcinogenesis

Correlation between Lactate Dehydrogenase Isozyme Patterns of Mammalian Livers and Dietary Environments

The Physiological Significance of LDH-X

Studies on the Activity of Selected Enzymes and Isozymes in Experimental Heart Infarct in Dogs

Isozyme Patterns in Tissues of Temperature-Acclimated Fish

Temperature Adaptation: Isozymic Function and the Maintenance of Heterogeneity

The Roles of Isozymes in Adaptation to Varying Temperatures

Cyclic Nucleotide-Dependent Protein Kinases from Eukaryotic Organisms

Single Reactions with Multiple Functions: Multiple Enzymes as One of Three Patterns in Microorganisms

Comparative Studies of Multiple Peptide Hydrolases from Guinea Pig Small Intestinal Mucosa and the Implications of These Studies for the "Missing Peptidase" Hypothesis for Coeliac Disease

Genetic Control and Epigenetic Modification of Human Serum Cholinesterase

Potentials in Exploring the Physiological Role of Acetylcholinesterase Isozymes

Molecular Pathology of the Multiple Forms of Fibrinogen and Its Fragments

Malate Dehydrogenase Isozymes in Plants: Preparation, Properties, and Biological Significance

Multiple Molecular Forms of the Purine Phosphoribosyl Transferases

The Significance of Multiple Molecular Forms of Acetylcholinesterase in the Sensitivity of Houseflies to Organophosphorus Poisoning

Localization of Creatine Kinase Isozymes in Muscle Cells: Physiological Significance Regulation of Human Glutamine Phosphoribosylpyrophosphate Aminotransferase by Interconversion of Two Forms of the Enzyme

Studies on Human Lysosomal ß-D-N-Acetyl Hexosaminidase and Arylsulfatase Isozymes

DNA-Dependent RNA Polymerase Species from Rat Liver Tissue

Physiological and Pathological Significance of Human Pyruvate Kinase Isozymes in Normal and Inherited Variants with Hemolytic Anemia

Aldehyde Oxidizing Enzymes in Locusta migratoria

Forms and Functions of Gluconeogenic Enzymes in Arthropods

Different Molecular Forms of Formate Dehydrogenase and Nitrate Reductase Solubilized from the Membrane of Escherichia coli

Isozymes of Aspartate Aminotransferase and Glycogen-Phosphorylase in Muscles of Lower Vertebrates

Spectroscopic Probes of Enzyme-Coenzyme-Substrate Complexes of Aspartate Transaminases

Isozymes of Adenosine Deaminase

Isozymes of Sheep Liver Threonine Deaminase

Properties and Physiological Significance of Multiple Forms of Mitochondrial Monoamine Oxidase (MAO)

The Use of Isozymes in the Study of Mitochondria

Isozymes of Phosphoenolpyruvate Metabolism

Possible Role for Superoxide and Superoxide Dismutase in G6PD Type Hemolytic Anemia

Functional Aspects of "Nothing Dehydrogenase" Polymorphism in the Pike-Perch (Lucioperca lucioperca L.)

Subcellular Localization of Rat Kidney Glutaminase Isozymes and Their Role in Renal Ammoniagenesis

Role of Adenylylated Glutamine Synthetase Enzymes and Uridylylated Regulatory Protein Enzymes in the Regulation of Glutamine Synthetase Activity in Escherichia coli

Selection Mechanisms Maintaining Alcohol Dehydrogenase Polymorphisms in Drosophila melanogaster

-Glutamyl Transpeptidase: Properties in Relation to Its Proposed Physiological Role

Comparative Physical, Chemical, and Enzymic Properties of the Isozymic Forms of Avian Aldolases and Fructose Diphosphatases

Regulation of Multiple Forms of Amino Acid Catabolizing Enzymes in Rat Liver

The Hexokinase Isozymes: Sulfhydryl Considerations in the Regulation of the Particle-Bound and Soluble States

Physiological Significance of Phosphofructokinase Isozymes

Substrate Specificities of Plant Peroxidase Isozymes

The Isoperoxidases of Cucurbita pepo L

Two Pairs of Isozymes in the Aromatic Biosynthetic and Catabolic Pathways in Neurospora crassa

Separation of Atypical and Usual Forms of Human Serum Cholinesterase by Affinity Chromatography

Index