International Review of Experimental Pathology

International Review of Experimental Pathology, Volume 30, is organized around the theme of renal disease. The choice of renal disease reflects both the author's personal interest and the realization that there is a need for such a collection of reviews in this area. There are many new books on renal pathology, but almost all have a clinical rather than experimental orientation.
The book opens with a chapter on the pathogenesis of experimentally induced renal papillary necrosis and upper urothelial carcinoma. Subsequent chapters deal with the use of cell cultures in the study of renal diseases; mechanisms of cyclosporine nephrotoxicity in humans and animal systems; spontaneously occurring renal diseases in laboratory animals; and the use of video microscopy to define the reactivity of the renal microvasculature and the hydraulic permeability of the glomerular capillaries.
This book will be of interest to a diverse group of readers interested in renal disease. This broad spectrum of potential readership is reflected in the list of contributors which includes, in addition to pathologists, nephrologists, anatomists, veterinarians, and experimental chemists. This volume will also be of interest to transplant surgeons and to pediatricians specializing in renal disease.

Contenu

Preface
Experimentally Induced Renal Papillary Necrosis and Upper Urothelial Carcinoma
I. Introduction
II. Renal Papillary Necrosis and Upper Urothelial Carcinoma in Humans
III. Experimentally Induced Renal Papillary Necrosis
IV. Use of Model Papillotoxic Probes to Study the Pathogenesis and Secondary Development of Renal Papillary Necrosis
V. Biochemical Interpretation of the Pathogenesis and Secondary Consequences of Renal Papillary Necrosis
VI. Renal Papillary Necrosis and Upper Urothelial Carcinoma
VII. Summary of the Pathogenesis of Experimentally Induced Renal Papillary Necrosis and Upper Urothelial Carcinoma
VIII. Remaining Questions
References
The Contribution of Cell Culture to the Study of Renal Diseases
I. Introduction
II. Glomerular Cell Culture
III. Tubular Cell Culture
References
Cyclosporine Nephrotoxicity
I. Introduction
II. Experimental Models of Cyclosporine Nephrotoxicity
III. Clinical Cyclosporine Nephrotoxicity
IV. Future Directions and Unanswered Questions
References
Glomerular Antigens in Experimental Glomerulonephritis
I. Models of Glomerulonephritis
II. Structure and Function of the Glomerulus
III. Immune Mechanisms in the Pathogenesis of Glomerulonephritis
IV Antigens in Experimental Glomerulonephritis
V Genetic Influences
VI. Conclusion
References
Spontaneous Renal Disease in Laboratory Animals
I. Introduction
II. Rat
III. Mouse
IV. Hamster
V Rabbit
VI. Guinea Pig
VII. Dog
VIII. Monkey
References
The Use of Video Imaging Techniques to Study Ultrafiltration and Blood Flow in the Normal and Diseased Kidney
I. Background
II. Documentation of Filtration by Isolated Glomeruli
III. Studies of Isolated Renal Microvessels
IV Observations of Glomeruli during In Situ Perfusion
V Studies of Blood-Perfused Juxtamedullary Nephrons
VI. Documentation of Medullary Blood Flow
VII. Prospects for the Future
References
Chemically Induced Renal Epithelial Neoplasia in Experimental Animals
I. Introduction
II. Renal Tubule Epithelial Cell Neoplasia
References
Index