Inflammation, Aging, and Oxidative Stress

The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer's disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson's disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging.

Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer's Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.

Auteur

Arezoo Campbell received a B. A. in philosophy, a B. S. in biological sciences and a Ph.D. in environmental toxicology from the University of California, Irvine (UCI) in Irvine, California. She is currently an Associate Professor in the Department of Pharmaceutical Sciences at Western University of Health Sciences. Dr. Campbell's research emphasizes the means by which environmental exposures induce aberrant innate immune responses, which may accelerate the appearance of age-related neurodegenerative disease. Dr. Campbell also investigates the importance of inflammatory and oxidative stress in contributing to adverse changes within the brain.Stephen Bondy received an M. A. in biochemistry from Cambridge University, in Cambridge, England and his Ph.D. in neurochemistry from Birmingham University, in Birmingham, England. He subsequently held appointments at Columbia University, University of California Los Angeles, University of Colorado, and theNational Institutes of Environmental Health Sciences. He is currently a Professor in the Center for Occupational and Environmental Medicine at the University of California, Irvine. His research focuses on identifying environmental factors which may accelerate brain aging, with emphasis on understanding the mechanisms that may underlie these events. In addition, Dr. Bondy is pursuing the development of therapeutic approaches with the potential to slow neurodegenerative processes.

Contenu

Part I) Relation between adverse oxidant and inflammatory changes.- 1)Relationship between inflammatory and oxidative pathways in the disease process.- 2) Nitric oxide, the common denominator in oxidative and inflammatory events.- 3) Genomic profiling of the link between oxidative and inflammatory events.- 4) Environmental toxicants inflammation and oxidative stress.- Part II) Role of oxidative events in age-related diseases.- 5) Mitochondrial DNA deletions and oxidative stress.- 6) Oxidative stress and Alzheimer's disease.- 7) Oxidative stress and Parkinson's disease.- 8) Oxidative stress, cause or consequence of aging?.- 9) Oxidative events in intracellular signaling.- 10) Oxidative stress and drugs of abuse.- Part III) Role of inflammatory events in age-related diseases.- 11) Limitations of animal models of human inflammatory disease.- 12) Microglial activation in neurodegenerative diseases.- 13) Particle- induced inflammation and cardiovascular disease.- 14) Microglia and inflammation in Parkinson's disease.- Part IV) Modulation of disease by anti-oxidant and anti-inflammatory agents.- 15) Alzheimer's disease and anti-oxidant therapy.- 16) Antioxidant, and behavioral therapy in slowing brain aging .- 17) Treatment of age-related disease using micronutrients.- 18)Anti-inflammatory treatment in neurological disease.