Impact of Molecular Biology and New Technical Developments in Diagnostic Imaging

Diagnostic imaging relies primarily on morphological criteria. However, there is an incereasing need for more disease-spcific informatin. New developments in imaging techniques and in molecular biology provide new imaging strategies to address functional and disease-specific parameters for clinical and scientific applications. The acquisition of functional and disease-specific information may lead to true "molecular imaging" which benefits from intensive collaboration between biologists, clinicians and physicists. This workshop formed the platform for an intensive discussion between experts in the fields of molecular biology and diagnostic imaging on basic principles, current methodology and future perspectives of MR, ultrasound and scintigraphic imaging approaches. This book is a comprehensive summary of the presentations and sicussions of the workshop. It provides the reader with the state-of-the-art informationi on diagnostic imaging and the links to molecular biology that are necessary for the development of molecular imaging.

Texte du rabat

New developments in the field of high resolution imaging focus on functional parameters pertaining to disease-specific medical imaging. Such new diagnostic strategies are possible using scintigraphic techniques and, more recently, by MRI and US. In addition, new therapeutic concepts, including gene therapy, require specific tracers or contrast media for therapy monitoring, for example, enzyme activity and changes in receptor expression. For this purpose scientists conducting basic research, expecially molecular biologists, and clinicians must collaborate in order to exploit the available interdisciplinary knowledge in the development of new imaging technologies so as to incorporate the molecular signals of diseases.

Contenu

1 Medical Imaging: Some Historical Aspects.- 2 Molecular Nuclear Medicine: From Genotype to Phenotype.- 3 Integrated Imaging of the Heart: New Clinical and Experimental Approaches.- 4 Principles and Clinical Applications of Functional Brain Imaging.- 5 Molecular Probing and Imaging by Magnetic Resonance Spectroscopy: Possibilities for Imaging Gene Therapy.- 6 Tumour Targeting Using Peptides, Monoclonal Antibodies and Fragments.- 7 Future Challenges in the Use of Positron Emission Tomography for In Vivo Molecular Imaging.- 8 Pharmacological Studies with Positron Emission Tomography.- 9 Use of Complex Carbohydrates as Targets and Ligands for Imaging.- 10 Oligonucleotide Aptamers as Specific Targeting Devices in Diagnostics and Therapy.- 11 In Vivo Monitoring of Gene Therapy by Radiotracer Imaging.- 12 Intra- and Intercellular Recognition of Cell Signaling Using Oligonucleotides.- Previous Volumes Published in this Series.