Hypothalamic Hormones

Hypothalamic Hormones is a collection of papers that elucidates the various aspects, chemical properties, effects, and history of hypothalamic hormones.
The book is composed of five chapters on the detailed study of hypothalamic hormones. Chapter 1 is about a review of basic and clinical studies of corticotropin releasing factor (CRF); thyrotropin releasing hormone (TRH); prolactin releasing factor; prolactin-release inhibiting factor; factors affecting the release of melanotropin; luteinizing hormone release hormone (LHRH); growth hormone release factor; and somatostatin. The second chapter is a discussion on the various aspects of luteinizing hormone release hormone (LHRH). Subsequent chapters are concerned with the study of factors that control the secretion of growth hormone, with particular emphasis on brain neurotransmitters; the mechanism of action of hypothalamic hormones; and effects of androgens, estrogens, and other peripheral hormones on the hypothalamus function. The last chapter gives a history of neurosecretion and neuroendocrinology.
Biochemists, physicians, pharmacologists, endocrinologists, researchers, and students in the medical field will find this book invaluable.

Contenu

List of Contributors
Preface
Contents of Previous Volumes

1. Hypothalamic Peptide Hormones: Basic and Clinical Studies
   I. Introduction
   II. Corticotropin-Releasing Factor (CRF)
   III. Thyrotropin-Releasing Hormone (TRH)
   IV. Prolactin-Releasing Factor (PRF)
   V. Prolactin-Release-Inhibiting Factor (PIF)
   VI. Factors Affecting the Release of Melanocyte-Stimulating Hormone (MSH)
   VII. The LH- and FSH-Releasing Hormone (LH-RH/FSH-RH)
   VIII. Growth Hormone-Releasing Factor (GH-RF)
   IX. Growth Hormone Release-Inhibiting Hormone (GH-RIH, Somatostatin)
   References
2. Gonadoliberin
   I. Introduction
   II. Extraction and Purification of Gonadoliberin from Different Sources
   III. Determination of the Primary Structure of Gonadoliberin
   IV. Conformational Studies on Gonadoliberin
   V. Chemical Syntheses of Gonadoliberin
   VI. Structure-Activity Relationship for Gonadoliberin
   VII. Gonadoliberin Biosynthesis and Biodegradation
   VIII. Control of Gonadoliberin Release
   IX. Biological Effects of Gonadoliberin
   X. Bioassay for Gonadoliberin
   XI. Immunological Studies with Gonadoliberin
   XII. Cellular Mechanism of Action of Gonadoliberin
   XIII. Agonist and Antagonist Analogues of Gonadoliberin
   XIV. Concluding Remarks
   References
3. The Control of Somatotropin Secretion
   I. Introduction
   II. Secretion Pattern of GH in Different Animal Species
   III. Stimuli for GH Secretion
   IV. Central Nervous System Control of GH Secretion
   V. Feedback Control of GH Secretion
   VI. Concluding Remarks
   References
4. Mechanisms of Action of Hypothalamic and Peripheral Hormones in the Anterior Pituitary Gland
   I. Introduction
   II. Role of Cyclic AMP in the Action of TRH, LH-RH, and Somatostatin
   III. Role of Prostaglandins in Hypothalamic Hormone Action on Adenohypophysis
   IV. Adenohypophyseal Cyclic AMP-Dependent Protein Kinase and Its Substrates
   V. Interactions between LH-RH, Sex Steroids, and Inhibin in the Control of LH and FSH Secretion
   VI. Antagonism between Estrogens and Thyroid Hormone in the Control of TSH Secretion: Role of TRH Receptors
   VII. The Pituitary Dopamine Receptor: Potent Antidopaminergic Activity of Estrogens on Prolactin Secretion
   References
5. Neurosecretion and Neuroendocrinology in Historical Perspective
   I. Introduction
   II. Discovery of Neurosecretory Neurons
   III. One-Step Neurohormonal Activities
   IV. Neuroendocrine Axis
   V. Nonneurohormonal Functions of Peptidergic Neurons
   VI. Biochemistry of Neurosecretory Products
   VII. Developmental Relationships and the APUD Concept
   VIII. Conclusions
   References
   Author Index
   Subject Index