Humoral Factors in Host Defense

Humoral Factors in Host Defense contains the proceedings of the First Takeda Science Foundation Symposium on Bioscience, held on October 28-30, 1982, in Kyoto, Japan. The symposium focused on the humoral factors regulating immune responses, with emphasis on T cell-derived immunoregulatory molecules; molecular mechanisms of interferons; factors involved in differentiation and activation of immunocytes; and the use of the molecular genetics approach to host defense factors.
Organized into four parts encompassing 22 chapters, this volume begins with an overview of interleukin-2 and T cell-replacing factors, along with their immunological functions and biochemical features. It then discusses antigen-specific T cell factors; immunoregulatory molecules from human monoclonal T cells; physiological and pathological roles of lymphokines; regulation of the immune system by monoclonal T cell peptides; production of a glycosylated human protein by recombinant DNA technology; and molecular genetics of immunoglobulin genes and the major histocompatibility antigen.
Geneticists and biologists will find this book extremely useful.

Contenu

Contributors
Foreword
Preface
T Cell-Derived Immunoregulatory Molecules

1. Immunological Functions and Biochemical Characterizations of IL-2 and T Cell-Replacing Factors
   Immunological Function and Biological Characterization of T Cell-Replacing Factor and Its Acceptor Site(s) on B Cells
   The Hormonal Basis for T Cell Growth
   B Cell Activation
2. Antigen Specific T Cell Factors
   Control of the Immune System by Monoclonal T Cell Peptides
   An Antigen-Specific Suppressor Cell Factor Composed of Two Distinct Polypeptide Chains
3. Immunoregulatory Molecules from Human Monoclonal T Cells
   Immunoregulation of Human B Lymphocyte Function by Products of Hybridized and Cloned T Cells
   Regulation of Proliferation and Differentiation of B Lymphocytes by T Cell-Derived Immunoregulatory Molecules
   Interferon
4. Interferon Genes
   Production of a Glycosylated Human Protein by Recombinant DNA Technology
   Expression of the Human Interferon- Gene in Heterologous Host Cells
5. Molecular Mechanisms of Interferon Action
   Interferon Action and the Role of 2-5A
   Interferon Action: (A) Interferons as Inducers of mRNA and Protein Synthesis (B) Cross-Linking of Mouse-Beta Interferon to Cell Surface Receptors
6. Purification and Molecular Properties
   Characterization of Mouse Interferon Molecules
   The Human Interferons: Their Purification and Sequence, Cloning and Expression in Bacteria, and Biological Properties
   Factors Involved in Differentiation and Activation of Immunocytes
   Physiological and Pathological Roles of Lymphokines
   The Function and Regulation of Macrophages Bearing I-Region-Associated Molecules
   A Current View of Interleukin I
   Characterization of Three Human Migration Inhibitory Factors (MIF) and Their Specific Production by Different Antigens
   Lymphokine-Producing Human T Cell Hybridomas
   Molecular Genetic Approach to Host Defense Factors
7. Molecular Genetics of Immunoglobulin Genes
   Immunoglobulin Lambda Genes: Structure, Evolution, and Expression
   Human Immunoglobulin Genes
8. Molecular Genetics of Major Histocompatibility Antigen
   Class II Genes of the Major Histocompatibility Complex in Mice
   HLA-DR Region Proteins and Genes
   Index