Humoral Control of Growth And Differentiation

Humoral Control of Growth and Differentiation, Volume I: Vertebrate Regulatory Factors is a part of two-volume work that introduces the reader to humoral control of growth and differentiation in vertebrates. This volume gives emphasis on chemical messengers, which have received relatively little attention in standard treatises on endocrine physiology for a number of reasons.
Organized into three parts, this book begins with the physiological significance of chalones. This class of hormones is intimately associated with mitotic homeostasis as inhibitors of cell division. The book then looks into the aspects of blood cell formation and release, as well as the humoral control of organs and tissue growth. This volume also includes chapters discussing the humoral changes occurring in diseases of the blood and other pathologic states. The humoral factors influencing lymphocyte proliferation in culture are also explained. Moreover, this volume examines the effects of the more orthodox hormones upon skeletal growth and regeneration.

Contenu

List of Contributors
Preface
Contents of Volume II
I Chalones

1. Chalone Control Systems
   I. Introduction
   II. Mitotic Control: Positive Feedback
   III. Mitotic Control: Negative Feedback
   IV. Mitotic Control in Epidermis
   V. Epidermal Chalone and Stress Hormones
   VI. Other Chalone Systems
   VII. Characteristics of Chalones
   VIII. The Chalone Mechanism
   IX. The Epidermal Response to the Epidermal Chalone
   X. Wound Healing and Tissue Regeneration
   XI. Carcinomata
   XII. The Pattern of Tumor Growth
   XIII. General Conclusions
   References
   II Blood Cell Formation and Release
2. Erythropoietin: The Humoral Regulator of Erythropoiesis
   I. Introduction
   II. Erythropoietin
   III. General Conclusions
   References
3. Humoral Regulation of Neutrophil Production and Release
   I. Historical Background
   II. Stem Cells
   III. Proliferation and Maturation of Neutrophils
   IV. Cellular and Humoral Regulation of Neutrophil Release
   V. Regulation within the Circulation
   VI. Regulatory Events in an Inflammatory Reaction
   VII. Possible Mechanisms Regulating Neutrophil Production and Release
   VIII. Problems to Be Resolved
   References
4. Humoral Regulation of Eosinophil Production and Release
   I. Introduction
   II. Eosinapheresis as a Methodological Approach for the Study of the Control of Eosinophil Production
   III. The Humoral Control of Leukopoiesis: General Mechanisms and Some Speculations on Factors Controlling Eosinopoiesis
   IV. Summary
   References
5. The Colony Stimulating Factor (CSF)
   I. Granulocytic and Macrophage Colony Formation
   II. Nature and Origin of Colony Stimulating Factor
   III. Mechanism of Action of CSF in Vitro
   IV. Origin and Metabolism of CSF
   V. Effects of CSF in Vivo
   VI. Summary
   References
6. Humoral Regulation of Thrombocytopoiesis
   I. Introduction
   II. Alterations in Thrombocytopoiesis under Changing Demands for Circulating Platelets
   III. Thrombopoietin and Its Assay
   IV. Mode of Action of Thrombopoietin
   V. Regulation of Termination of DNA Synthesis
   VI. Summary
   References
7. Humoral Aspects of Blood Cell Dyscrasias
   I. Introduction
   II. Humoral Aspects of Erythropoiesis
   III. Humoral Aspects of Thrombocytopoiesis
   IV. Humoral Aspects of Leukopoiesis
   V. Conclusions
   References
8. Regulation of Erythopoiesis in Lower Vertebrates
   I. Introduction
   II. Studies in Frogs
   III. Studies in Birds
   IV. Studies in Fish
   V. Species and Class Specificity of Mammalian and Submammalian Ep
   VI. Comments and Conclusions
   References
9. Humoral Regulation of Lymphocyte Growth in Vitro
   I. Introduction
   II. Soluble Activities Derived from Leukocytes Stimulating or Potentiating Lymphocyte Growth in Vitro
   III. Factors Involved in Lymphocyte-Macrophage Interaction
   IV. Soluble Activities Present in the Culture Environment Stimulating or Potentiating Lymphocyte Growth in Vitro
   V. Biological Significance of Different Stimulating or Potentiating Activities
   VI. Soluble Substances Derived from Leukocytes Inhibiting Lymphocyte Growth in Vitro
   VII. Soluble Substances Present in the Culture Environment Inhibiting Lymphocyte Growth in Vitro
   VIII. Studies on Growth Modifying Agents in Different Diseases
   IX. Conclusion
   References
10. Possible Feedback Inhibition of Leukemic Cell Growth: Kinetics of Shay Chloroleukemia Grown in Diffusion Chambers and Intraperitoneally in Rodents
    I. Introduction
    II. Materials and Methods
    III. Results
    IV. Discussion
    V. Summary
    References
    III Humoral Control of Organs and Tissue Growth
11. The Nerve Growth Factor
    I. Introduction
    II. Structural Properties of NGF
    III. Distribution of NGF
    IV. Biological Properties of NGF
    V. Immunosympathectomy
    VI. Metabolic Effects of NGF
    VII. Concluding Remarks
    References
12. Humoral Aspects of Liver Regeneration
    I. Introduction
    II. Experimental Results
    III. Conclusion
    References
13. Renal Growth Factor
    I. Introduction
    II. Denervated, Transplanted Kidney
    III. Kidneys in Vascular Parabiosis
    IV. Problems in Assays
    V. Transfer of Serum
    VI. Tissue Extracts
    VII. Growth Regulators versus Work Hypertrophy
    VIII. Search for the Factor
    IX. Summary
    References
14. Hormonal Influence on Skeletal Growth and Regeneration
    I. Introduction
    II. The Hierarchy of Skeletal Cell Compartments
    III. Somatotropic Hormone (Growth Hormone, STH)
    IV. Thyroid Hormone
    V. Androgens and Gonadotropins
    VI. Estrogens and Progestogens
    VII. Adrenocorticotropic Hormone (ACTH) and Adrenocortical Hormones
    VIII. Insulin
    IX. Parathyroid Hormone (PTH)
    X. Thyrocalcitonin (Calcitonin, TCT)
    XI. Parotin
    XII. Summary
    References
15. Trauma and Tumor Growth with Special Emphasis on Wound Stress and "Wound Hormones"
    I. Introduction
    II. Long-Term Effects of Trauma on Tumor Induction
    III. Immediate Effects of Trauma on Tumor Growth in Experimental Animals
    IV. Effect of Cell and Wound Tissue Factors
    V. Wound Hormones
    VI. The Effect of Stress on Metastases
    VII. Endocrine Effects of Trauma
    VIII. Other Effects of Stress on Cell Proliferation
    IX. Summary
    References
16. General Summary
    Author Index
    Subject Index