Hsp90 in Cancer: Beyond the Usual Suspects

Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression.

• Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins
• Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology
• Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression

Contenu

1. Unusual Suspects in the Twilight Zone between the Hsp90 Interactome and Carcinogenesis
   Evangelia Vartholomaiou, Pablo C. Echeverría and Didier Picard
   
   2. Impact of Post-translational Modifications on the Anticancer Activity of Hsp90 Inhibitors
      Mark R. Woodford, Diana Dunn, Jonelle B. Miller,Sami Jamal, Len Neckers and Mehdi Mollapour
   3. Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects
      Gaurav Garg, Anuj Khandelwal and Brian S. J. Blagg
   4. HSP90 in Cancer: Transcriptional Roles in the Nucleus
      S. K. Calderwood and L. Neckers
   5. Hsp90 as a 'Chaperone' of the Epigenome: Insights and Opportunities for Cancer Therapy
      Jennifer S. Isaacs
   6. Emerging Roles of Extracellular Hsp90 in Cancer
      Daniel Senh Wong and Daniel G. Jay
   7. GRP94/gp96 in Cancer: Biology, Structure, Immunology and Drug Development
      Bill X Wu, Feng Hong, Yongliang Zhang, Ephraim Ansa-Addo and Zihai Li
   8. HSP90 and Immune Modulation in Cancer
      Michael W. Graner
   9. Hsp90: A Global Regulator of the Genotype-To-Phenotype Map in Cancers
      Daniel Jarosz