Hormonal Steroids Biochemistry, Pharmacology, and Therapeutics

Hormonal Steroids: Biochemistry, Pharmacology, and Therapeutics, Volume I focuses on various research on steroids and their biological and medical involvements.
Comprised of 60 chapters, the book presents the literature of various authors who have conducted research on the relationship between hormonal steroids and biochemistry, pharmacology, and therapeutics. The discussions start with the identification of steroids with hormone-like activities. This discussion includes the nature, compositions, properties, possible uses, and reactions of these hormones when exposed to different conditions and controlled environments.
The book then proceeds with discussions on synthesis and metabolism of hormonal steroids. These discussions are supported by graphical representations, reviews, recommendations, and methodologies. The book then explains the control of synthesis and release of steroid hormones. This part notes the relationship of renal and adrenal hormones; the control and production of corticosterone; neurosecretion and control of the pituitary gland; and release of ovulating hormones. The book also highlights the mechanism of steroid action, noting the probable interrelationships of steroids, nonsteroids, intermediary metabolism, and inflammation. Various research are presented on the possible clinical applications of steroids.
The text is a vital reference for readers who are interested in the study of hormones.

Contenu

Contributors to Volume 1

Foreword

Contents of Volume 2

Symposium 1 New Steroids With Hormone-Like Activities

Inverted Steroids, their Preparation and Biological Activities

Ether Derivatives of Steroidal Hormones

Discussion. The Influence of Enol Etherification on the Biological Activity of 3-Ketosteroids

New Steroids with Hormone-Like Activities: C-6 Substituted Hormone Analogs

Discussion. Pharmacological Aspects of the Study of Chlormadinone

Antiandrogenic, Antiestrogenic and Antiovulatory Compounds

Discussion

The Actions of "Retro" Progestagens

Discussion. Possible Uses of Retrosteroid Derivatives in Humans

Biological Properties of 4-Hydroxy-3-Keto-Steroids

Discussion. Applications of Ring A Modifications of 4-Hydroxy-3-Keto-Steroids

Symposium 2 Pathways of Synthesis and Metabolism of Hormonal Steroids

Some Aspects of Steroid Dynamics

Discussion. Ring A and Side-chain Reduction Processes in Cortisol Metabolism

Interaction of Thyroid with Steroid Hormone Metabolism

Discussion. Thyroid and Steroid Hormone Metabolism

The Metabolism and Localization in Tissues of Tritium-Labeled Steroid Sex Hormones

Discussion. Comments on the Biological and Biochemical Aspects of the Experiments

In Vitro Conversion of Deoxycorticosterone to Some Acidic Metabolites

Discussion. In Vitro Conversion of Deoxycorticosterone to Some Acidic Metabolites

Symposium 3 Control of Synthesis and Release of Steroid Hormones

Neurohumoral Factors from the Brainstem and Epiphysis

Discussion

Interrelationship of Renal and Adrenal Hormones

Discussion. Interrelationship of Renal and Adrenal Hormones

Hypothalamic Control of the Production of Corticosterone

Discussion. Effect of Hypothalamic Lesions

The Regulation of ACTH and Corticosteroid Secretion

Discussion

The Inhibiting Action of Adrenocortical Steroids on ACTH Secretion

Discussion. Neurosecretion and Control of the Pituitary Gland

Adrenal Cortical Function in Dogs with Central Nervous System Ablations

Discussion. Hypothalamus and Release of Ovulating Hormone

Neural Aspects of the Feedback Action of Ovarian Steroids

Discussion. Neural Aspects of the Feedback Action of Ovarian Steroids: The Role of Progesterone

Electrolytic Irritative Lesions in the Hypothalamus and Other Forebrain Areas: Effects on Luteinizing Hormone Release and the Ovarian Cycle

Discussion

Regulation of Luteinizing Hormone (LH) Secretion by a Hypothalamic LH-Releasing Factor

Discussion. Control of Ovulating Hormone Release

Synthesis and Release of Progestin by Rabbit Ovary in Vivo

Effects of Hypothalamic Deconnection of the Pituitary Control of Testosterone Secretion

Discussion. Effects of Pituitary Transplantation in Birds

Symposium 4 Mechanism of Steroid Action

The Role of Molecular Configuration in the Interaction of Steroid Hormones with Coenzymes and Enzymes

Discussion

Steroid Metabolism and Steroid Action

Discussion. Adrenal Steroids and Adipose Tissue

Steroids, Nonsteroids, Intermediary Metabolism, Inflammation and their Probable Interrelationships

Discussion. Aspects of the Anti-inflammatory Action of Prednisolone

Possible Mode of Action of Adrenocortical Steroids

Discussion. Glucocorticoids and Alanine a-Ketoglutarate-Transaminase Activity

The Mode of Action of Cortisol upon Lymphocytes

On Mechanism of Steroid Action at the Molecular Level

Symposium 5 Substances Which Affect Synthesis and Action of Steroid Hormones

Nonhormonal Inhibitors of Adrenocortical Steroid Biosynthesis

Discussion. Nonhormonal Inhibitors of Adrenocortical Steroid Biosynthesis: Clinical Applications

Studies on Adrenocortical Inhibitors

Discussion

Incretory Modifications Induced by Administration of an Inhibitor of 11-Hydroxylase (Su-4885) in Different Functional Conditions of the Diencephalic-Hypophyseal-Adrenal System

The Effects of Treatment with 19-Norsteroids on the Secretion and Metabolism of Cortisol and of Aldosterone in Women

Discussion. Interaction of Steroid Hormones

Action of Antialdosterone Compounds in the Laboratory

Discussion. Aldosterone Antagonism and Aldosterone Inhibition

The Actions of Steroid Hormones on Estradiol-17 in Uterine Growth and Enzymorphology

Symposium 6 Nonhormonal Activities of Steroids

Steroids that Act on the Nervous System

Discussion. Specificity of Steroid Action

Direct and Indirect Effects of Deoxycorticosterone (DOC) on Skeletal Muscle Electrolyte and Acid-Base Metabolism

Discussion. Effects of Anti-inflammatory Steroids on Electrolite Metabolism

The Effect of Estrogens, Androgens, and Corticoids on Skeletal Dynamics in Man

Discussion. Evaluation of the Strontium Tracer Technique in the Study of Skeletal Dynamics

Inotropic Actions of Certain Steroids upon Cardiac Tissue

Discussion. Actions of Certain Steroids upon Cardiac Tissue

The Action of Steroids on the Skin

Discussion. Influence of Steroids on the Melanocytes of the Skin

Hormonal Factors in Aging

Discussion. Action of Estrogens on the Skin

Influence of Steroids on Enzymatic Activities and Permeability of Cells, Mitochondria, and Lysosomes

Subject Index