Hormonal Proteins and Peptides

Hormonal Proteins and Peptides, Volume I reviews extensively the knowledge on the biology and chemistry of the protein and peptide hormones. This book presents the structures of the various protein and peptide hormones.

Organized into five chapters, this volume begins with an overview of the chemistry of several hormonal glycoproteins. This text then presents the research on the purification and chemistry of thyroid-stimulating hormone (TSH). Other chapters consider the study of ovine interstitial cell-stimulating hormone, and concentrate to some extent on the very closely related bovine species. This book discusses as well some aspects of the biology of the pituitary interstitial cell-stimulating hormone or luteinizing hormone in mammalian species. The final chapter deals with the correlation of the primary structure with function for a better understanding of the mechanism of action of the hormone at a molecular level.

This book is a valuable resource for biologists, biochemists, and research workers.

Contenu

List of Contributors
Preface
Contents of Volume II

1. The Chemistry of Glycoproteins
   Text
   References
2. The Chemistry of Pituitary Thyrotropin
   I. Introduction
   II. Preparation of Bovine TSH
   III. Purification of Human TSH
   IV. The Subunits of Bovine TSH and Their Linear Amino Acid Sequences
   V. The Carbohydrate Portion of Bovine TSH
   VI. A Comparison of the Molecular Parameters of Bovine TSH Determined Directly and as Deduced from the Sequence
   VII. The Chemical and Biological Relationships Between TSH, LH, and HCG (Human Chorionic Gonadotropin)
   VIII. Comparative Studies-Human TSH
   IX. Problems and Possibilities
   References
3. The Chemistry of the Interstitial Cell-Stimulating Hormone of Ovine Pituitary Origin
   I. Introduction
   II. Purification of Ovine ICSH
   III. Physical Properties of Ovine ICSH
   IV. Chemical Properties of Ovine ICSH
   V. The Subunit Nature of ICSH
   VI. Structural Studies on the ICSH Subunits
   VII. Comments on the Heterogeneity of ICSH
   VIII. Concluding Remarks
   References
4. The Biology of Pituitary Interstitial Cell-Stimulating Hormone
   I. Introduction
   II. Gonadotropic Factors of the Pituitary Gland
   III. Biological Effects of ICSH in the Female
   IV. Role of ICSH in Pregnancy
   V. Formation and Maintenance of Corpus Luteum
   VI. Biological Effects of ICSH in the Male
   VII. Extragonadal Actions of ICSH
   VIII. Regulation of ICSH Secretion
   IX. Metabolism of ICSH
   X. Effects of ICSH on Gonadal Metabolism
   XI. Concluding Remarks
   References
5. Chemistry of Human Chorionic Gonadotropin
   I. General
   II. Methods of Purification of HCG
   III. Physicochemical Properties
   IV. Chemical Composition
   V. Amino and Carboxy Terminal Analyses
   VI. Quaternary Structure of HCG
   VII. Investigation of the Carbohydrate Units in HCG
   VIII. Amino Acid Sequence of HCG
   IX. General Considerations
   References
6. Chemistry and Biosynthesis of Thyroid Iodoproteins
   I. Introduction: Definitions and Classifications
   II. Chemistry of Thyroid Iodoproteins
   III. Biosynthesis of Thyroid Iodoproteins
   References
   Author Index
   Subject Index