Homeostasis, Nephrotoxicity, and Renal Anomalies in the Newborn

This is the 11th of the Pediatric Nephrology series created to help us be in touch with developments which are relevant to the problems we face daily in clinical practice and the questions we ask and try to answer in clinical and experimental research. Like volume IX, this one focuses on one of the subgroups to which we are committed--the neonates' special fluid and electrolyte requirements. This volume has more on blood pressure and renal function and looks at the hormonal regulators. There is greater depth about intoxications and nephrotic agents, congenital disorders and mineral metabolism. The exchanges were stimulating and the controversies were brought out without need of much of my usual prodding. At Julie Ingelfinger's suggestion, at the end of each panel discussion I have added a comment to highlight the main points as I see them. Otherwise, the format remains as in past editions: the papers given related to the four major topic areas, each followed by panel and registrant discussion. Although the transcription is almost verbatim, you will not find the names of the discussants, purposely omitted to ease my editorial work and to encourage everyone to speak candidly. Some of the questions and answers are those submitted to the panelists after the sessions, incorporated here by request. Also, frequent references are made to others' work but their names have been omitted.

Contenu

I Control of Blood Pressure and Sodium Homeostasis.- Development of Adrenergic and Dopamine Receptors in the Kidney.- Prostaglandin-Angiotensin Interactions for Blood Pressure Regulation.- Renal Handling of Sodium During Development.- Clinical Overview of Neonatal Hypertension.- Panel Discussion.- II Intoxications - Nephrotic Agents.- Risk Factors in Nephrotoxicity.- Aminoglycoside Nephrotoxicity - Clinical and Experimental Observations.- Management of Acute Renal Failure Due to Nephrotoxic Agents. Sorbent Hemoperfusion.- Acute Dialysis and Ultrafiltration in the Newborn.- Panel Discussion.- III Congenital Disorders.- Syndromes with Renal Malformations.- Natural History of Congenital Anomalies of the Kidney and Urinary Tract.- Renal Tubular Acidosis.- New Diagnostic Imaging Procedures in Neonatal Renal Disease.- Panel Discussion.- IV Mineral Metabolism.- Early Neonatal Hypocalcemia.- Late Neonatal Hypocalcemia.- Pharmacologic Agents to Reverse Hypercalcemie and Hypocalcemie States.- Renal Hypophosphatemic Rickets.- Continuous Peritoneal Dialysis in Infancy with Particular Emphasis on the Neonatal Period.- Insufficiency and Resistance to Parathyroid Hormone.- Panel Discussion.- V Special Lectures.- Functional Immaturity of the Newborn Kidney-Paradox or Prostaglandin?.- Continuous Ambulatory Peritoneal Dialysis in Infants and Children.- VI Workshop.- Case Presentations and Discussion.- Participants.- Author Index.