Non-Neoplastic Hematopathology and Infections

Most books on hematopathology are neoplastic in scope and offer
little non-neoplastic content. In Non-Neoplastic Hematopathology
and Infections, the authors fully describe the hematologic
manifestations in tissue and blood of infectious agents, including
many rare and exotic diseases found in both Western and Eastern
hemispheres, in order to assist pathologists and medical laboratory
professionals all over the world in better diagnosing and treating
such infections.

Thoroughly illustrated with photographs, tables and text, this
book features a wide range of non-neoplastic hematologic disorders,
as well as reactive patterns of non-infectious and infectious
agents. Comprehensive and state-of-the-art diagnostic materials are
described, as are the epidemiology, pathobiology, clinical and
pathologic manifestations in blood and lymphatic organs--as
well as the approaches to treatment.

In addition, Non-Neoplastic Hematopathology and
Infections:

• Contains detailed information on the pathology and patterns of
  blood, lymph node, and a number of bone marrow and splenic
  infections and infectious agent manifestations

• Thoroughly updates the classic pathology of reactive
  lymphadenopathies and extends this pattern-based approach to
  tropical and emergent infections

• Promotes the multidisciplinary integration of hematopathologists
  and microbiologists in the analysis and diagnostic work-up of
  tissue and blood

• Complements current major treatises on such tropical diseases as
  Manson's, Ashworth's, and Doerr's and updates the classic tomes of
  William St. Clair Symmers and current texts on neoplastic
  hematopathology

Non-Neoplastic Hematopathology and Infections is an
important book for any medical professional interested in
non-neoplastic hematology, infections and tissue hematopathology,
infectious diseases and tropical medicine, and tropical
hematopathology.

Auteur

Hernani Cualing MD, is Associate Professor in the Department
of Pathology and Cell Biology and Director of the Hematopathology
Fellowship Training Program at the University of South Florida
College of Medicine in Tampa, Florida. He is also an active
hematopathologist at the Moffitt Cancer Center and Research
Institute there. In addition to his research into such topics as
mantle cell and T cell lymphomas, Dr. Cualing has long been
fascinated with the analysis, diagnosis, and treatment of
non-neoplastic and infectious blood, marrow, and lymph diseases.

Parul Bhargava, MD, is Medical Director in the Hematology
Laboratory at Beth Israel Deaconess Medical Center-Needham Campus
in Boston, and a staff and faculty physician in the Pathology
department there. Her primary research interests are in studying
hematopoietic neoplasms and newer markers in Hodgkin Lymphoma, but
she also has a strong, separate clinical interest in studying the
effects of immunodeficiency and infections, particularly HIV, on
the hematopoietic system.

Ramon L. Sandin, MD, MS, FCAP, ABP-MM, is a Clinical
Pathologist and Medical Director of Clinical Microbiology and
Virology in the Department of Hematopathology, Laboratory Medicine,
and in the Blood and Marrow Transplant Program at the Moffitt
Cancer Center in Tampa, Florida 33612-9497. His special areas of
expertise and research interests are in clinical microbiology and
virology, and laboratory diagnosis of infectious diseases. This
includes 'wet' laboratory work-ups and tissue section diagnosis as
well as molecular diagnostic techniques.

Résumé
Most books on hematopathology are neoplastic in scope and offer little non-neoplastic content. In Non-Neoplastic Hematopathology and Infections, the authors fully describe the hematologic manifestations in tissue and blood of infectious agents, including many rare and exotic diseases found in both Western and Eastern hemispheres, in order to assist pathologists and medical laboratory professionals all over the world in better diagnosing and treating such infections. Thoroughly illustrated with photographs, tables and text, this book features a wide range of non-neoplastic hematologic disorders, as well as reactive patterns of non-infectious and infectious agents. Comprehensive and state-of-the-art diagnostic materials are described, as are the epidemiology, pathobiology, clinical and pathologic manifestations in blood and lymphatic organsas well as the approaches to treatment.

In addition, Non-Neoplastic Hematopathology and Infections:

• Contains detailed information on the pathology and patterns of blood, lymph node, and a number of bone marrow and splenic infections and infectious agent manifestations

• Thoroughly updates the classic pathology of reactive lymphadenopathies and extends this pattern-based approach to tropical and emergent infections

• Promotes the multidisciplinary integration of hematopathologists and microbiologists in the analysis and diagnostic work-up of tissue and blood

• Complements current major treatises on such tropical diseases as Manson's, Ashworth's, and Doerr's and updates the classic tomes of William St. Clair Symmers and current texts on neoplastic hematopathology

Non-Neoplastic Hematopathology and Infections is an important book for any medical professional interested in non-neoplastic hematology, infections and tissue hematopathology, infectious diseases and tropical medicine, and tropical hematopathology.

Contenu
Contributors, xix Foreword, xxiii

Preface, xxv

Acknowledgments, xxvii

Introduction, xxix

PART I Non-neoplastic Hematology 1

CHAPTER ONE Non-neoplastic Disorders of White Blood Cells 3
Rebecca A. Levy, Vandita P. Johari, and Liron Pantanowitz

Overview of WBC Production and Function, 3

Quantitative Disorders of WBCS, 6

Qualitative Disorders of WBCS, 21

References, 26

CHAPTER TWO Non-neoplastic Disorders of Platelets 31
Lija Joseph

Platelet Production Structure and Function, 31

Quantitative Disorders of Platelets, 33

Qualitative Disorders of Platelets, 39

References, 43

CHAPTER THREE Approach to Disorders of Red Blood Cells 45
Jason C. Ford

Introduction, 45

The Anemias, 45

The Approach to Anemia, 50

The Polycythemias, 63

References, 63

CHAPTER FOUR Microcytic, Normocytic, and Macrocytic Anemias 65
Reza Setoodeh and Loveleen C. Kang

Microcytic Anemias, 65

Normocytic Anemias, 74

Macrocytic Anemias, 81

References, 86

CHAPTER FIVE Disorders of Hemoglobin 89
Parul Bhargava

Overview, 89

Quantitative Disorders of Hemoglobin, 89

Qualitative Disorders of Hemoglobin, 97

MixedQuantitative Qualitative Disorders of Hemoglobin, 104

Double Heterozygous States, 105

Approach to Diagnosis of Hemoglobin Disorders, 106

References, 111

PART II Infectious Aspects of Hematology 113

CHAPTER SIX Apicomplexal Parasites of Peripheral Blood, Bone Marrow, and Spleen: The Genera Plasmodium, Babesia, and Toxoplasma 115
Lynne S. Garcia

Plasmodium, 115

Babesia, 125

Toxoplasma, 128

References, 134

CHAPTER SEVEN Blood and Tissue Flagellates of the Class Kinetoplastidea: The Genera Leishmania and Trypanosoma 139
Raul E. Villanueva and Stephen D. Allen

Leishmaniasis, 139

Chagas' Disease, 145

African Trypanosomiasis, 150

References, 155

CHAPTER EIGHT Proteobacteria and Rickettsial Agents: Human Granulocytic Anaplasmosis and Human Monocytic Ehrlichiosis 159
Sheldon Campbell and Tal Oren

Microbiology and Epidemiology of HGA and HME, 159

Clinical Syndromes, 160

Differential Diagnosis, 160

Diagnostic Approach, 161

Prevention and Treatment, 163

References, 163

CHAPTER NINE **Clinic…