Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response

The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monograph, with its leading authorship, presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It contains state-of-the-science reviews on invasion, metastasis, angiogenesis, apoptosis and immunologic aspects related to cancer.

Contenu

Metastasis: a current perspective.- Control of cell motility during tissue invasion.- Cell adhesion and invasion during secondary tumor formation: interactions between tumor cells and host organs.- Genes and metastasis: experimental advances and clinical implications.- The evolution of diversity within tumors and metastases.- Tumor angiogenesis, antiangiogenic therapy and anti-antiangiogenesis response.- Apoptosis and cancer.- Macrophages in tumour development and metastasis.- Classical and alternative activation of macrophages: different pathways of macrophage-mediated tumor promotion.- Characterization of tumor-directed cellular immune responses in humans.- Immunological aspects of Marek's disease virus (MDV)-induced lymphoma progression.- Abnormal variation of the immune response as related to cancer.- A biodynamical model of human T-cell development and pathology: design, testing and validation.