Growth Hormone and Related Proteins

Hormonal Proteins and Peptides, Volume IV: Growth Hormone and Related Proteins deals with various aspects of somatotropin or growth hormone, and its related proteins.

This book begins by discussing the bioassay methods for somatotropin, followed by a review of the in vitro lipolytic actions of the hormone. The chemistry of human chorionic somatomammotropin (HCS) and human somatotropin (HGH) are compared and deliberated in detail. This publication concludes with an analysis of the control of prolactin secretion, including an account of the development of the hypophysectomy technique in the rat and effect of hypophysectomy on various bodily functions in experimental animals.

This volume is a good reference for endocrinologists, medical practitioners, and researchers conducting work on growth hormones.

Contenu

List of Contributors
Preface
Contents of Previous Volumes

1. Bioassay of Pituitary Growth Hormone
   I. Introduction
   II. Weight Increase of Normal Plateaued Rats
   III. Weight Increase of Hypophysectomized Rats
   IV. Weight Increase of Dwarf Mice
   V. Increase in Tail Length of Hypophysectomized Rats
   VI. Increase in the Width of the Proximal Tibial Epiphysis of Hypophysectomized Rats
   VII. The Tibia Test
   VIII. The Tibia Test in Hypophysectomized Mice
   IX. Increase in the Longitudinal Bone Growth of Proximal Tibia in Hypophysectomized Rats
   X. Stimulation of Hepatic Ornithine Decarboxylase Activity
   XI. Stimulation of Sugar Transport in Isolated Diaphragm of Hypophysectomized Rats
   XII. Miscellaneous Methods
   XIII. Concluding Remarks
   References
   Note Added in Proof
2. Growth Hormone and the Regulation of Lipolysis
   I. Introduction
   II. Demonstration of Involvement of GH in Lipid Mobilization
   III. Physiology of Adipose Tissue and the Importance of Free Fatty Acids
   IV. Effects of GH on FFA Release in Vivo
   V. Stimulation of Lipolysis by GH in Vitro
   VI. Conclusions
   References
3. The Chemistry of Human Chorionic Somatomammotropin
   I. Introduction
   II. Isolation and Characterization as a Pure Substance
   III. Molecular Properties
   IV. Structure-Function Relationships
   V. Concluding Remarks
   References
4. Control of Prolactin Secretion
   I. Introduction
   II. Hypothalamic Control
   III. Agents Other than Biogenic Amines That Influence Prolactin Secretion
   IV. Location of Areas of the Brain That Influence Prolactin Secretion and Nervous Pathways Involved
   V. Relation of Prolactin to Secretion of Gonadotropins
   VI. Prolactin Receptor Binding Activity in Different Tissues
   VII. Relation of Prolactin to Secretion of ACTH, GH, and TSH
   VIII. Some Unique Aspects of Control of Prolactin Secretion in Man
   References
5. Hypophysectomy and Philip E. Smith
   I. Introduction
   II. Amphibian Research
   III. Mammalian Research
   IV. Growth
   V. Pituitary-Thyroid Relationship
   VI. Pituitary-Gonad Relationship
   VII. Monkeys
   VIII. Reflections
   References
   Author Index
   Subject Index