Growth Factors

Hormonal Proteins and Peptides: Growth Factors, Volume XII focuses on the chemistry and biology of nerve growth factor (NGF), insulin-like growth factors/somatomedins/multiplication-stimulating activity (IGFs/SMs/MSA), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), and skeletal growth factor (SGF). This book discusses the development of growth factors in cell proliferation, differentiation, and malignancy.
Organized into eight chapters, this volume starts with an overview of the findings on the structural and biological properties of NGF. This text then discusses the identical amino acid sequences of IFG-I and SM-c and explains as well the similarities in the structure of IFG-II and MSA. Other chapters present a thorough discussion of human PDGF, with emphasis on the link between the PDGF and the simian sarcoma virus gene product. This book discusses as well the mechanism of action of the pituitary and brain FGF. The final chapter deals with the discovery, isolation, and characterization of the biological activities of epidermal growth factor (EGF).
This book is a valuable resource for biochemists, endocrinologists, and physicians.

Contenu

Contributors
Preface
Contents of Previous Volumes
1 The Nerve Growth Factor (NGF)
I. Introduction and Brief Survey of Early Findings
II. Large and Small Biological Sources of NGFs
III. Chemical and Structural Properties of NGF
IV. Hormonal Control of NGF Synthesis
V. Biological Effects of Endogenous Salivary Gland NGF
VI. Biological Effects of NGF in Living Organisms and In Vitro Experimental Systems
VII. The Mechanism of Action of NGF
VIII. Temporal Dissection of NGF Effects in PC 12 Cells
IX. Concluding Remarks and Perspectives
References
2 Insulin-like Growth Factors, Somatomedins, and Multiplication Stimulating Activity: Chemistry
I. Introduction
II. Purification
III. Amino Acid Sequence
IV. Models of the Three-Dimensional Structure
V. Chemical Synthesis
VI. Concluding Remarks
References
3 The Somatomedins: Biological Actions and Physiologic Control Mechanisms
I. Introduction
II. Methods of Detection and Quantitation
III. In Vitro Biological Effects of the Somatomedins
IV. In Vivo Effects
V. Relationship between Growth Hormone and Somatomedin
VI. Physiologic Regulation of Serum Somatomedin Concentrations
VII. Conclusion
References
4 Insulin-like Growth Factors: Biosynthesis, Receptors, and Carrier Proteins
I. Introduction
II. Biosynthesis of Insulin-like Growth Factors
III. IGF Receptors
IV. IGF Carrier Proteins
V. Conclusions
References
5 Brain and Pituitary Fibroblast Growth Factors
I. Introduction
II. Purification and Characterization of Pituitary and Brain Fibroblast Growth Factors
III. Effect of Pituitary and Brain FGF on Cultured Cells
IV. Mechanism of FGF Action
V. The Extracellular Matrix and the Control of Cell Proliferation
VI. Plasma Factors Involved in the Proliferation of Normal Diploid Cells
VII. In Vivo Effect of FGF
VIII. Conclusion
References
6 Human Platelet-Derived Growth Factor
I. Introduction
II. Studies Leading to the Recognition of PDGF
III. Purification and Characterization of PDGF
IV. Amino Acid Sequence and Structural Identity between PDGF and the Simian Sarcoma Virus Transforming Protein
V. PDGF and Malignant Transformation
VI. Physiologic Functions of PDGF
VII. Platelet-Derived Mitogens for Tumor Cells
VIII. Production of PDGF-like Polypeptides by Human Malignant Cells in Culture
IX. Possible In Vivo Functions of PDGF
References
7 Skeletal Growth Factor
I. Introduction
II. Historical Perspective
III. Purification of Skeletal Growth Factors
IV. Properties of Skeletal Growth Factors
V. Function of Skeletal Growth Factor
VI. Unanswered Questions
References
8 Epidermal Growth Factor (EGF): Historical Perspectives
I. Introduction
II. Characterization
III. Determination of Mode of Action
IV. Research Applications
References
Index