The Control of Fertility

The Control of Fertility is concerned with the experimental control of fertility as a specific biological problem. It is, first of all, an attempt to summarize a collection of data hitherto either partially or not at all presented. Secondly, it attempts to indicate those avenues which hold promise for future investigation. Finally, it attempts an assessment of the implications of understandings and ignorances.
The book opens with an account of the sequence of processes essential to successful sexual reproduction in mammals. This is followed by separate chapters on approaches to the inhibition of spermatogenesis, ovulation, fertilization, and free ovum development. Subsequent chapters deal with blastocyst development and implantation, biological activities of compounds affecting fertility, fertility control in men and women, the inhibition of ovulation, biological properties of ovulation inhibitors in human subjects, and effectiveness and acceptability of contraception.

Contenu

Preface
Acknowledgments
I. Introduction

1. Backgrounds
   Text
   References
2. The Reproductive Processes and Their Vulnerabilities in Mammals
   Processes in the Male
   Processes in the Female
   References
   II Animal Studies
3. Spermatogenesis and Semen
   Pituitary and Gonadotropin Inhibition
   Direct Effects on Testis Tissue
   Semen and Seminal Fluid
   References
4. Ovulation
   The Hypothalamopituitary Axis
   Steroidal Ovulation Inhibitors
   Antigonadotropin Assay
   Antigonadotropins and the Hypothalamus
   Inhibition of Exogenous Gonadotropin
   Miscellaneous Antigondotropic Agents
   References
5. Fertilization
   Text
   References
6. Free Ovum Development
   Text
   References
7. Blastocyst Development and Implantation
   Ovarian Hormones and Implantation Processes
   Extra-Ovarian Influences on Implantation
   The Lability of Implantation Processes
   Estrogens and Anti-Estrogens
   Antiprogestins
   Poisons and Antimetabolites
   Intrauterine Trauma
   Corpus Luteum Inhibition
   Abortion
   References
8. Some Biological Activities of Compounds Affecting Fertility
   Some Activities of Estrogens
   Anti-Estrogens
   Estrogens and Androgens
   The Activities of Gestagens
   Effects on Fetuses
   Hormones and Tumors
   The Metabolism of Compounds Affecting Fertility
   References
   III Clinical Studies
9. Control of Fertility in Men
   Text
   References
10. Fertility in Women-Ovogenesis and Ovulation
    Fertility Potential in Women
    Detection of Ovulation
    The Stimulation of Ovulation
    References
11. The Inhibition of Ovulation
    The Assay of Ovulation Inhibitors in Human Subjects
    Contraception
    References
12. Some Biological Properties of Ovulation Inhibitors in Human Subject
    Functions Associated with Reproductive Organs and Processes
    Mammary Glands and Lactation
    Pregnancy and Postpartum
    Functions Associated with Other Endocrine Organs
    Effects on Somatic Tissues and Functions
    Weight Gain and Aspects of Organic Metabolism
    Hematology
    Skin and Related Tissues
    Psychological Effects
    References
13. Some Consequences of the Application of Fertility Control
    The Effectiveness of Contraception
    The Acceptability of Contraception
    References
    Author Index
    Subject Index