Grand Challenges in Fungal Biotechnology

This volume provides a comprehensive overview of the major applications and potential of fungal biotechnology. The respective chapters report on the latest advances and opportunities in each topic area, proposing new and sustainable solutions to some of the major challenges faced by modern society. Aimed at researchers and biotechnologists in academia and industry, it represents essential reading for anyone interested in fungal biotechnology, as well as those working within the broader area of microbial biotechnology. Written in an accessible language, the book also offers a valuable reference resource for decision-makers in government and at non-governmental organizations who are involved in the development of cleaner technologies and the global bioeconomy.

The 21st century is characterized by a number of critical challenges in terms of human health, developing a sustainable bioeconomy, facilitating agricultural production, and establishing practices that support a cleaner environment. While there are chemical solutions to some of these challenges, developing bio-based approaches is becoming increasingly important.

Filamentous fungi, 'the forgotten kingdom,' are a group of unique organisms whose full potential has yet to be revealed. Some key properties, such as their exceptional capacity to secrete proteins into the external environment, have already been successfully harnessed for the production of industrial enzymes and cellulosic biofuels. Many further aspects discussed here -such as feeding the hungry with fungal protein, and the potential applications of the various small molecules produced by fungi -warrant further exploration.

In turn, the book covers the use of fungal cell factories to produce foreign molecules, e.g. for therapeutics. Strategies including molecular approaches to strain improvement, and recent advances in high-throughput technologies, which are key to finding better products and producers, are also addressed. Lastly, the book discusses the advent of synthetic biology, which is destined to greatly expand the scope of fungal biotechnology.

The chapter "Fungal Biotechnology in Space: Why and How?" is available open access under a Creative Commons Attribution 4.0 International License at link.springer.com.

Auteur

Professor Helena Nevalainen is one of the pioneers in Fungal Biotechnology and has published widely on the topic. She has worked both in industry and academia in Finland and Australia, which has provided her a unique view of Fungal Biotechnology and challenges in the field globally. She has extensive experience from a number of Biotechnology Program steering committees and as an expert consultant to industry. She is currently Professor of Biotechnology at Macquarie University in Australia where she has acted as Director of Masters in Biotechnology Program and graduated several postgraduate students who have since moved on to leading positions nationally and internationally. She has active collaborations with several distinguished scientists and has also acted as an editor and guest editor in Fungal Biotechnology book series and specialist journals.

Contenu

Section 1: Fungal Biotechnology and the Global Challenges

• Chapter 1: Fungal Biotechnology: Unlocking the Full Potential of Fungi for a More Sustainable World

Lene Lange, Jane Agger, Anne S. Meyer

• Chapter 2: Fungal Attack on Environmental Pollutants Representing Poor Microbial Growth Substrates

Dietmar Schlosser

• Chapter 3: The Biotechnology of Quorn Mycoprotein: Past, Present and Future Challenges

Jack A. Whittaker, Robert I. Johnson, Tim J.A. Finnigan, Simon V. Avery, Paul S. Dyer

• Chapter 4: The Current Biotechnological Status and Potential of Plant and Algal Biomass Degrading/Modifying Enzymes from Ascomycete Fungi

Ronald P. de Vries, AleksandrinaPatyshakuliyeva, Sandra Garrigues, ShebaAgarwal-Jans

Section 2: Developments in Key Enabling Technologies

• Chapter 5: Genetic Transformation of Filamentous Fungi: Achievements and Challenges

Alexander Lichius, Dubraska Moreno Ruiz, Susanne Zeilinger

• Chapter 6: Bottlenecks and Future Outlooks for High-Throughput Technologies for Filamentous Fungi

Kyle Rothschild-Mancinelli, S German, Mikael R. Andersen

• Chapter 7: Strategies and Challenges for the Development of Industrial Enzymes Using Fungal Cell Factories

José Arnau, Debbie Yaver, Carsten M. Hjort

• Chapter 8: Meeting a Challenge: A View on Studying Transcriptional Control of Genes Involved Plant Biomass Degradation in Aspergillus niger

Jing Niu, Arthur F.J. Ram, Peter J. Punt

Section 3: Towards BioeconomyPotential of Fungal Biotechnology

• Chapter 9: The Economic Potential of ArbuscularFungal Biotechnology in Agriculture

Maya Benami, YochaiIsack, Dan Grotsky, Danny Levy, Yossi Kofman

• Chapter 10: Molecular and Genetic Strategies for Enhanced Production of Heterologous LignocellulosicEnzymes Sophie A. Comyn, Jon K. Magnuson

Section 4: Branching Out Emerging Opportunities

• Chapter 11: Horizontal Gene Transfer in Fungi

Erin L. Bredeweg, Scott E. Baker

• Chapter 12: Spotlight on Class I Hydrophobins: Their IntriguingBiochemical Properties and Industrial Prospects

Paola Cicatiello, Ilaria Sorrentino, Alessandra Piscitelli, Paola Giardina

• Chapter 13: An Aroma Odyssey: The Promise of Volatile Fungal Metabolites in Biotechnology

Victoria L. Korn, Sally Padhi, Joan W. Bennett

• Chapter 14: Fungal Peroxygenases: A Phylogenetically Old Superfamily of Heme Enzymes with Promiscuity for Oxygen Transfer Reactions

Martin Hofrichter, Harald Kellner, Robert Herzog, Alexander Karich, Christiane Liers, KatrinScheibner, Virginia Wambui Kimani, René Ullrich

• Chapter 15: Progress and Research Needs of Plant Biomass Degradation by Basidiomycete Fungi

Miia R. Mäkelä, Kristiina Hildén, Joanna E. Kowalczyk, Annele Hatakka

• Chapter 16: Organic Acids in the TCA Cycle: The Building Blocks of the Future

J. Stefan Rokem

• Chapter 17: Opportunities for New Generation Ganodermaboninense Biotechnology

NishaGovender, Wong Mui-Yun, Robert Russell Monteith Paterson

• Chapter 18: Fungal Biotechnology in Space: Why and How?

Marta Cortesão, TabeaSchütze, Robert Marxc Ralf Moeller, Vera Meyer