Glial-Neuronal Signaling in Neuroendocrine Systems

This volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today.

Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication.

Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems.

This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.

Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Auteur
Jeffrey Tasker received his B.A. from the University of Colorado in 1981 and his M.S. equivalent and Ph.D. from the University of Bordeaux II in 1986, working with Drs. Dominique Poulain and Dionysia Theodosis. He then joined Dr. F. Edward Dudek's lab for his postdoctoral research at the UCLA Neuropsychiatric Institute. He joined the faculty of Tulane University in 1991, where he currently holds the positions of Professor of Cell and Molecular Biology and Endowed Chair in Neuroscience. His research focuses on the neural circuit, electrical and molecular mechanisms of neuronal, astroglial, and neuroendocrine control of physiological homeostasis, the stress response, and stress disorders.
Dr. Jaideep Bains is a Professor of Physiology and Pharmacology and a member of the Hotchkiss Brain Institute at the University of Calgary, Canada. He received his Ph.D. from Queen's University (Canada) in 1997. He established his lab at the University of Calgary in 2001. His research uses electrophysiology, optogenetics, imaging and behavior to understanding how neurons, astrocytes, and brain circuits are modified by stress.

Julie A. Chowen received her B.S. from Lake Superior State University in 1982 and her Ph.D. in Physiology from the University of Washington in 1990. She joined Dr. Luis Miguel García-Segura's laboratory at the Cajal Institute for Neuroscience in Madrid for her postdoctoral research. In 1999 she established her laboratory in the Department of Endocrinology at the Hospital Infantil Niño Jesús in Madrid. Her research focuses on the neuroendocrine control of metabolism, early nutritional and hormonal influences on long-term metabolism and the role of astrocytes in mediating metabolic signals.

Contenu

PART I Glial-Neuronal Interactions in the Control of Hypothalamic Development

Chapter 1: The role of microglia in the developing hypothalamus - Deborah Kurrasch

PART II Glial-Neuronal Interactions in the Control of the Magnocellular Neuroendocrine System

Chapter 2: Structural dynamics in the hypothalamic-neurohypophysial system

Seiji Miyata

Chapter 3: Functional consequences of morphological plasticity in the adult hypothalamo-neurohypophysial system

Daniel L Voisin, Aude Panatier, Stéphane H Oliet

Chapter 4: Synaptic scaling by astrocytes Grant S.J. Gordon and Jaideep S. Bains

Chapter 5: Glial control of extrasynaptic receptor signaling in hypothalamic neurons

Javier Stern

PART III Glial-Neuronal Interactions in the Control of Metabolic Function

Chapter 6: Astrocytes in the brain control of systemic metabolism

O Le Thuc, T. Gruber, Matthias H. Tschoep, and Cristina García-Cáceres

Chapter 7: Astrocyte mediation of metabolic hormone effects on energy homeostasis Julie A. Chowen

Chapter 8: Glia-neuron communication: Not a one-way street

Denise D. Belsham

PART IV: Glial-Neuronal Interactions in the Control of the Stress Response

Chapter 9: Neuronal-glial synaptic circuits in the hypothalamus Juhee Haam, Zhiying Jiang, Jeffrey G. Tasker

PART V Glial-Neuronal Interactions in the Control of Reproductive Function

Chapter 10: Microglia, hormones, and behavior

Jaclyn M. Schwarz, Margaret M. McCarthy

Chapter 11: The role of astrocytes in estrogen positive feedback

Paul Micevych

PART VI Glial-Neuronal Interactions in the Control of the Blood-Brain Barrier

Chapter 12: Unveiling the importance of tanycytes in the control of the dialogue between the brain and the periphery

Vincent Prevot

Chapter 13: Tanycyte-neuronal interactions: Novel mechanisms for regulation of the thyroid axis Ronald Lechan, Csaba Fekete