Wound Healing, Fibrosis, and the Myofibroblast

Wound Healing, and the Myofibroblast: A Historical and Biological Perspective is the fruit of an interdisciplinary and international collaboration involving a historian of medicine (Dr. Zampieri), a physician (Dr. Coen), and a researcher (Prof. Gabbiani, world-renowned for his discovery of the myofibroblast). This book aims to draw a concise yet complete description of the conceptual evolution of wound healing, fibrosis and fibrosis-related pathologies from antiquity to present time, as well as commenting on the role of the myofibroblast and the key cell type essential for tissue repair and fibrosis (from its identification in 1971 throughout its 50-years-old history).

By viewing this complex and century-long history from different perspectives, the book's authors aim to draw an exhaustive overview, with the hope of inspiring new and fruitful basic and clinical research.

• Interdisciplinary collaboration: complementary views from medical historian, a physician and a researcher
• A concise but detailed history of fibrosis, readers can discover the major scientific breakthroughs along this history
• Includes the pathophysiology of various fibrotic diseases
• Explores the role of myofibroblast in fibrosis development

Auteur

Giulio Gabbiani has obtained an MD degree at the University of Pavia (Italy) and a PhD degree at the University of Montreal (Canada). He has been Research Associate at the Department of Pathology of Harvard Medical School, Professor at the Department of Pathology and Immunology of the University of Geneva (Switzerland), where he is now Emeritus Professor. He has been Secretary and President of the European Cytoskeleton Forum, Secretary and Chairman of the European Vascular Biology Association, Secretary of the European Tissue Repair Society. He has received several distinctions including a degree of Doctor Honoris Causa from the University of Gothenburg (Sweden) and from the University of Limoges (France). Giulio Gabbiani's interests span from the biology of the myofibroblast (which he discovered in 1971), to mechanisms of fibrosis development and to the biology of arterial smooth muscle cell including its involvement in atherosclerosis.

Contenu

1. Introduction 2. Fibrous Tissue, Fibrosis and the Fibroblast 3. Wound healing and Wound Contraction 4. Fibrotic Diseases 5. The Myofibroblast: Role in Fibrosis Development 6. Conclusions and Perspectives 7. Bibliography