Biostatistics

A respected introduction to biostatistics, thoroughly updated and revised
The first edition of Biostatistics: A Methodology for the Health Sciences has served professionals and students alike as a leading resource for learning how to apply statistical methods to the biomedical sciences. This substantially revised Second Edition brings the book into the twenty-first century for today's aspiring and practicing medical scientist.
This versatile reference provides a wide-ranging look at basic and advanced biostatistical concepts and methods in a format calibrated to individual interests and levels of proficiency. Written with an eye toward the use of computer applications, the book examines the design of medical studies, descriptive statistics, and introductory ideas of probability theory and statistical inference; explores more advanced statistical methods; and illustrates important current uses of biostatistics.
New to this edition are discussions of

Longitudinal data analysis
Randomized clinical trials
Bayesian statistics
GEE
The bootstrap method
Enhanced by a companion Web site providing data sets, selected problems and solutions, and examples from such current topics as HIV/AIDS, this is a thoroughly current, comprehensive introduction to the field.

GERALD VAN BELLE is a professor in the Departments of Biostatistics and Environmental and Occupational Health Sciences at the University of Washington in Seattle, Washington. He is the author of four books as well as more than 100 articles and numerous book chapters.
LLOYD D. FISHER is Professor Emeritus in the Department of Biostatistics at the University of Washington, Seattle, and a consultant to the drug and device industries. He has held positions with the Center for AIDS Research, the Mayo Clinic, and the Fred Hutchinson Cancer Center, among others.
PATRICK J. HEAGERTY is an associate professor in the Department of Biostatistics at the University of Washington in Seattle and an associate member at the Fred Hutchinson Cancer Research Center.
THOMAS LUMLEY is an associate professor in the Department of Biostatistics at the University of Washington in Seattle.

A respected introduction to biostatistics, thoroughly updated and revisedThe first edition of Biostatistics: A Methodology for the Health Sciences has served professionals and students alike as a leading resource for learning how to apply statistical methods to the biomedical sciences. This substantially revised Second Edition brings the book into the twenty-first century for today’s aspiring and practicing medical scientist.This versatile reference provides a wide-ranging look at basic and advanced biostatistical concepts and methods in a format calibrated to individual interests and levels of proficiency. Written with an eye toward the use of computer applications, the book examines the design of medical studies, descriptive statistics, and introductory ideas of probability theory and statistical inference; explores more advanced statistical methods; and illustrates important current uses of biostatistics.New to this edition are discussions of

• Longitudinal data analysis
• Randomized clinical trials
• Bayesian statistics
• GEE
• The bootstrap methodEnhanced by a companion Web site providing data sets, selected problems and solutions, and examples from such current topics as HIV/AIDS, this is a thoroughly current, comprehensive introduction to the field.

GERALD VAN BELLE is a professor in the Departments of Biostatistics and Environmental and Occupational Health Sciences at the University of Washington in Seattle, Washington. He is the author of four books as well as more than 100 articles and numerous book chapters.LLOYD D. FISHER is Professor Emeritus in the Department of Biostatistics at the University of Washington, Seattle, and a consultant to the drug and device industries. He has held positions with the Center for AIDS Research, the Mayo Clinic, and the Fred Hutchinson Cancer Center, among others.PATRICK J. HEAGERTY is an associate professor in the Department of Biostatistics at the University of Washington in Seattle and an associate member at the Fred Hutchinson Cancer Research Center.THOMAS LUMLEY is an associate professor in the Department of Biostatistics at the University of Washington in Seattle.

Auteur
LLOYD D. FISHER is Professor Emeritus in the Department of Biostatistics at the University of Washington, Seattle, and a consultant to the drug and device industries. He has held positions with the Center for AIDS Research, the Mayo Clinic, and the Fred Hutchinson Cancer Center, among others. PATRICK J. HEAGERTY is an associate professor in the Department of Biostatistics at the University of Washington in Seattle and an associate member at the Fred Hutchinson Cancer Research Center. THOMAS LUMLEY is an associate professor in the Department of Biostatistics at the University of Washington in Seattle.

Échantillon de lecture
1 A Great English Ship Moored Near the Grand Banks The cod were so thick we hardly have been able to row a boat through them. John Cabot
Head northeast in Newfoundland along the Bonavista Peninsula, until the rough road ends and the cold ocean begins, and you ll find a bronze statue of a man clothed in puffy Renaissance garb overlooking tumultuous seas. The landscape has a distinctly untamed feel to it as icebergs float offshore like errant mountaintops, humpback whales feed and breach, and puffins dart along the ocean surface to and from their island colony just around the point. That improbably dapper man is John Cabot who, in 1497, reached the New World the New Founde Land, as it was dubbed. Like Columbus five years before him, Cabot was an Italian sailor seeking a shortcut to the Orient. He figured that by heading north to where the longitudinal lines were closer, he d shave off some sailing days on his westward voyage to Asia. He figured wrong, of course. Cabot and his crew of eighteen ran into the invincible coast of eastern Canada and, instead of spices and porcelain, they found spruce, the oldest granite on Earth, and ice floes. Undaunted, Cabot claimed the region for the English throne, which had financed his expedition, then headed home. So enduring are the tales of Cabot s arrival hereabouts the peninsula s name is derived from the first words he was said to have uttered that it seems unfair to mention that Cabot s landing spot is wholly a matter of conjecture. Historians say Cabot may very well have made landfall around the Bonavista Peninsula, or perhaps in Nova Scotia on Cape Breton Island, where a similar statue also marks the event. Then again, maybe Cabot landed in Labrador (now part of the Province of Newfoundland and Labrador), or much farther south in Maine. No one knows for sure. While Cabot s landfall may be in dispute, what he discovered is not: cod and lots of them. Every school child knows the story. Five hundred years ago the explorer John Cabot returned from the waters around present-day Newfoundland to report that the codfish ran so thick they were easily caught by dangling a wicker basket over the side of the vessel. The log of Cabot s ship, the Matthew, reported there were six- and seven-foot-long codfish weighing as much as 200 pounds. Cabot discovered a resource that would shape world politics for hundreds of years, launch a fiercely competitive Maritime trade, and create safe harbours along the shores of the new colony of Newfoundland: the limitless bounty of the Grand Banks cod. Cabot led two explorations from Bristol, in 1497 and 1498. King Henry VII, who had agreed to his voyage and helped to pay for it, rewarded Cabot with the sum of £10. On his return to England, Cabot related amazing tales of this new world. Like witnesses in the New Testament, Cabot told tales of men who could walk across the Grand Banks waters on the backs of …