Genetics and Biotechnology

The Series

The fungi represent a heterogenous assemblage of eukaryotic microorganisms and have become favored organisms for research at the cellular and molecular level. Such research involvement has been stimulated by interest in the biotechnological application of fungi in processes related to industry, agriculture and ecology. Considering both yeasts and mycelial fungi, The Mycota highlights developments in both basic and applied research and presents an overview of fungal systematics and cell structure. Foremost authorities in research on mycology have been assembled to edit and contribute to the volumes.

This Volume

The first section of this volume, Genetics, illustrates the basic genetic processes underlying inheritance, cell biology, metabolism and "lifestyles" of fungi. The second section, Biotechnology, addresses the applied side of fungal genetics, ranging from new tools for synthetic biology to the biotechnological potential of fungi from diverse environments. Gathering chapters written by reputed scientists, the book represents an invaluable reference guide for fungal biologists, geneticists and biotechnologists alike.

Auteur

J. Philipp Benz (born 1977) studied biology at the TU Braunschweig (2003). The research work for his thesis was done in the laboratory of Nigel Crawford at UC San Diego (CA, USA). He subsequently performed his dissertation at the LMU Munich, working in the research group of Jürgen Soll (Department of Biochemistry and Physiology of Plants) (2009). He then returned to the USA to become a postdoctoral fellow in the laboratory of Chris Somerville at the Energy Biosciences Institute (UC Berkeley, CA, USA) where he started to work on filamentous fungi. In 2014, he was appointed assistant professor for Wood Bioprocesses at the Technical University of Munich (TUM School of Life Sciences Weihenstephan, Holzforschung München). His research group is studying the processes used by filamentous fungi to degrade lignocellulosic biomass. Central questions are how fungi perceive the composition of the plant biomass on a molecular level and how they adapt their metabolism to effectively degrade the substrate.

Kerstin Schipper (born 1980) completed her studies in biology at Osnabrück University in 2005. For the research work of her Master thesis she moved to the laboratory of Heinrich Jung at LMU Munich. She then performed her dissertation and a short post-doctoral time under the supervision of Regine Kahmann at the Max Planck Institute for Terrestrial Microbiology in Marburg in the field of plant-pathogen interactions. Since 2011 she is a group leader at the Institute for Microbiology at Heinrich Heine University Düsseldorf. Her work focusses on fungal biotechnology using the basidiomycete Ustilago maydis. Her major interest is a novel unconventional protein secretion pathway and its exploitation for production of heterologous proteins.

Texte du rabat

This fully revised third edition includes up-to-date topics and developments in the field, which has made tremendous strides since the publication of the second edition in 2004. Many novel techniques based on Next Generation Sequencing have sped up the analysis of fungi and major advances have been made in genome editing, leading to a deeper understanding of the genetics underlying cellular processes as well as their applicability. At the same time, the relevance of fungi is unbroken, both due to the serious threats to human health and welfare posed by fungal pests and pathogens, and to the many benefits that fungal biotechnology can offer for diverse emerging markets and processes that form the basis of the modern bioeconomy. With regard to these advances, the first section of this volume, Genetics, illustrates the basic genetic processes underlying inheritance, cell biology, metabolism and "lifestyles" of fungi. The second section, Biotechnology, addresses the applied side of fungal genetics, ranging from new tools for synthetic biology to the biotechnological potential of fungi from diverse environments. Gathering chapters written by reputed scientists, the book represents an invaluable reference guide for fungal biologists, geneticists and biotechnologists alike.

Résumé

Since publication of the first edition of Volume II in 1995, several developments in fungal molecular biology - such as fungal genome projects - have progressed tremendously. This in turn has affected fundamental genetics as well as biotechnology. To accommodate these developments, the second edition has been completely updated and all chapters have been revised. In addition, the volume contains five new chapters dealing with different aspects of fungal molecular genetics.

Topics include: Nuclear and extranuclear genetics; functional genomics; biotechnical genetics; yeasts and filamentous fungi.

Contenu

Molecular Genetics

1 Chromatin Structure and Function in Neurospora crassa

A.J. Courtney, A.R. Ferraro, A.D. Klocko, Z. LEWIS (U. of Georgia, USA) zlewis@uga.edu

2 Origin, function and transmission of accessory chromosomes

M. HABIG and E. HOLTGREWE STUKENBROCK (MPI für Evolutionsbiologie, D)

estukenbrock@bot.uni-kiel.de

3 Genetics of the unfolded protein response in fungi

R. Harting and K. HEIMEL (Uni Göttingen, D)

kheimel@gwdg.de

4 From genetics to molecular oscillations: the circadian clock in Neurospora crassa

M.S. JANKOWSKI, Z.A. CHASE and J.M. HURLEY (Rensselaer Polytech, USA) hurlej2@rpi.edu

5 small RNAs in fungi

F.E. Nicolás, L. Murcia, E. Navarro, J.T. Cánovas-Márquez, V. Garre (Univ. de Murcia, Spain)

vgarre@um.es

6 NLR function in fungi as revealed by the study of self/non-self recognition systems A. DASKALOV, W. DYRKA and S. SAUPE (CNRS, Bordeaux, F)

sven.saupe@ibgc.cnrs.fr

7 Genetics and genomics decipher partner biology in arbuscular mycorrhizas

L. Lanfranco, G. Carotenuto, A. Genre, P. Bonfante (Torino, Italy)

paola.bonfante@unito.it

8 Coordination of fungal secondary metabolism and development

J. GERKE, A.M. KÖHLER, C. MEISTER, K.G. THIEME, H. AMOEDO, G.H. BRAUS (Göttingen, D)

gbraus@gwdg.de

9 Fungal Genomics

R. OHM (Utrecht, NL)

r.a.ohm@uu.nl

Biotechnology

10 Filamentous fungi as hosts for heterologous production of proteins and secondary metabolites in the post-genomic era

J.K. Rendsvig, M.E. Futyma, Z.D. Jarczynska, U. H. MORTENSEN (DTU, Denmark)

um@bio.dtu.dk

11 New Avenues towards drug discovery in fungi

M. Flak, M.K.C. Krespach, A.J. Pschibul, V. Schroeckh, A.A. Brakhage (Jena, D)

axel.brakhage@uni-jena.de

12 Exploiting fungal photobiology as a source of novel bio-blocks for optogenetic systems

V. Rojas, F. Salinas, L. Guzman-Zamora, A. Romero, V. Delgado and L.F. LARRONDO (PUC, Chile)

llarrondo@bio.puc.cl

13 Yeast cell factories

B. Schmelzer, M. Altvater, B. Gasser, M. Sauer, D. MATTANOVICH (BOKU, Vienna, AUT)

diethard.mattanovich@boku.ac.at

14 Engineering Saccharomyces cerevisiae for production of fatty acids and their derivatives

L. Baumann, F. Wernig, S. Henritzi, M. OREB (Frankfurt)

M.Oreb@bio.uni-frankfurt.de

15 Fungi Involved in the Biodeterioration and Bioconversion of Lignocellulose Substrates

B. GOODELL (UMass)

bgoodell@umass.edu

16 Biotechnology of marine fungi: New workhorses and new uses - using marine fungal diversity as a source for biotechnology

A. Kramer, A. LABES (HS Flensburg, D)

antje.labes@hs-flensburg.de

17 The biotechnological potential of anaerobic gut fungi

V. Dollhofer, D. Young, S. Seppälä, C. Hooker, N. Youssef, S.M. Podmirseg, M. Nagler, M. Reilly, Y. Li, K. Fliegerová, Y. Chen…