G Protein-Coupled Receptors in Energy Homeostasis and Obesity Pathogenesis

Obesity is an epidemic with enormous health, economic and social burdens. Current drugs for obesity treatment are far from ideal in terms of efficacy and side effects. Reviews in this volume of Progress in Molecular Biology and Translational Science summarize current status in studies of a number of G protein-coupled receptors that were shown to be promising targets for obesity treatments. Some of these receptors also cause monogenic obesity in humans.

• Subject matter: obesity is an epidemic and G protein-coupled receptors are promising drug targets, with significant potential as new anti-obesity drugs
• Chapters are written by leading experts

Contenu

G Protein-coupled receptors in energy homeostasis and obesity: An introduction

Y. Tao Ghrelin receptor in energy homeostasis and obesity pathogenesis W. Zhang Obestatin receptor in energy homeostasis and obesity pathogenesis J. Zhang

Melanocortin-3 receptor in energy homeostasis and obesity pathogenesis

A. Butler

Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis

A. Hinney

G protein-coupled estrogen receptor in energy homeostasis and obesity pathogenesis H. Shi Relaxin-3 receptor in energy homeostasis and obesity pathogenesis C. Liu Cholecystokinin receptor in energy homeostasis and obesity pathogenesis

A. Sayegh

Adiponectin receptor in energy homeostasis and obesity pathogenesis. B. Akingbemi