Functional Aspects of the Normal, Hypertrophied, and Failing Heart

These Proceedings are from the Fifth Annual Meeting of the American Section of the International Society for Heart Research held at Hilton Head Island, South Carolina, September 21-24, 1983. The program and abstracts were published in the Journal of Molecular and Cellular Cardiology, Vol. 15, Supplement 4, September 1983, Academic Press. This Symposium Proceedings consists of three sections. Section I deals with the mechanical factors and their i'nfluence on coronary blood flow in the normal and failing heart. Section II is developed around the area of vascular smooth muscle and the factors that may control it which ultimately play such an important role in the regulation of coronary blood flow. Section III is primarily devoted to the mechanical aspects of the function of the heart in both hypertrophy and failure including the molecular changes in the myocyte, alterations in neural control, and in inotropic responsiveness of the hypertrophied and failing heart. The editors hope that these three areas encompass a significant body of new and ongoing information that will be helpful to those who work in these areas as well as those who treat patients with varying degrees of myocardial failure or with compromised coronary circulations. The editors express their appreciation to all the contributors and to Ms. Jeri B. McClain for assisting in the organization and compiling of this volume. Francis L. Abel, M. D. , Ph. D. Walter H. Newman, Ph. D.

Contenu

I Role of Mechanical Factors in the Regulation of Coronary Blood Flow in Normal and Failing Hearts.- 1 Capillary Monocyte Relationships in the Ventricular Wall.- 2 Role of Mechanical Factors in Coronary Inflow.- 3 Evolving Concepts of Coronary Pressure-Flow Relationships.- 4 Transmural Flow During Physiological Vasodilation.- 5 Regulation of Coronary Blood Flow in the Underperfused Ventricle.- II Vascular Smooth Muscle.- 6 Excitation, Contraction and the Distribution of Calcium and Sodium in Smooth Muscle.- 7 Role of the Na+ Pump in Vascular Smooth Muscle Contractility.- 8 Regulation of Myosin Phosphorylation in Smooth Muscle.- 9 Autonomic Nerves, Aggregating Platelets, and Contraction of Coronary Arterial Smooth Muscle.- III Functional Abnormalities of the Hypertrophied and Failing Heart.- 10 Subcellular Changes in Conpensated and Failing Hypertrophied Hearts.- 11 Autonomic Neural Control of the Failing Heart.- 12 The Inotropic Responsiveness of the Failing Heart.- 13 New Inotropic Drugs for the Treatment of Heart Failure.- 14 Transition to Cardiac Failure in Spontaneously Hypertensive Rats.- 15 Exercise and Pressure-Overload Induced Hypertrophy in Dog.- 16 Do the Limits of Molecular Adaptations Induce Failure of the Hypertrophied Heart?.- 17. Sarcolemmal Alterations in Cardiac Hypertrophy Due to Pressure Overload in Pigs.- 18 Structural Alterations in the Hypertrophied and Failing Myocardium.- 19 Myocardial Failure - The Mismatch of Subcellular Adaptive Changes.- 20 Mitochondrial Oxidative Phosphorylation and Calcium Transport in Cardiac Hypertrophy Due to Pressure Overload in Pigs.- 21 Abnormalities in the Calcium Pump Mechanism in Cardiomyopathy.- 22 Role of Calcium in Heart Function and Metabolism.- 23 Excitation-Contraction in Cardiac Muscle of the Adult and Senescent Rat.