Frontiers of Biological Energetics

Frontiers of Biological Energetics, Volume II: Electrons to Tissues contains most of the papers presented at the International Symposium on "Frontiers of Biological Energetics: Electrons to Tissues," held at the University of Pennsylvania School of Medicine in Philadelphia, Pennsylvania on July 20-21, 1978. The symposium provided a forum for discussing the common problems of biological energetics from different perspectives and from various levels of cellular organization.

Comprised of 84 chapters, this volume begins with a section on electrons and oxygen and covers topics ranging from the chemical constitutions and subunit function of cytochrome oxidase polypeptides to the structure and function of copper atoms in cytochrome oxidase. The next section deals with structural-functional approaches to membrane energetics and includes chapters that explore rhodopsin and bacteriorhodopsin in model membranes; the mechanism of free energy utilization for active transport of calcium ions; and the regulation of cytoplasmic calcium by liver mitochodria. The final section focuses on nondestructive measurements of tissue function, paying particular attention to phosphorus nuclear magnetic resonance of diseased muscle and extracellular oxygen gradients in shock, among other topics.

This book should be of interest to scientists from a variety of disciplines, including medicine and biology.

Contenu

Contributors of Volumes I and II
Preface
Part 4 Electrons and Oxygen
Cytochrome Oxidase Polypeptides: Chemical Constitutions and Subunit Function
Photoaffinity Labels for the Study of Cytochrome c and Phospholipid Interactions with Cytochrome c Oxidase
The Structure and Orientation of Cytochrome c Oxidase in Crystalline Vesicles
Are Cytochromes a and a3 on Opposite Sides of the Energy Conserving Membrane?
The Intra-Complex Electron Transfer From Cytochrome c1 to Cytochrome Oxidase and the Transient Appearance of Oxygenated Cytochrome Oxidase Compound I
Pre-Steady State and Steady-State Studies of Resting and Pulsed Cytochrome-c-Oxidase
The Magnetic Properties of Pseudomonas Cytochrome Oxidase
Structure and Function of Copper Atoms in Cytochrome Oxidase
EPR Probes of Cytochrome c Oxidase
A Model for the "Visible Copper in Cytochrome c Oxidase
Electron Nuclear Double Resonance of Cytochrome Oxidase
Resonance Raman and EPR Studies of Cytochrome Oxidase Ligand Complexes
Heme a Models for Cytochromes a and a3 in Cytochrome Oxidase Resonance Raman Studies
Evidence for Two Porphyrins A Present in Cytoplasmically and Mitochondrially Synthesized Subunits of Cytochrome c Oxidase
The Role of Cytochrome P-450 in the Formation of Superoxide and Hydrogen Peroxide
Reactions of Superoxide with Metalloporphyrins
The Formation of Horseradish Peroxidase Compound I
Electronic Configuration and Electromagnetic Properties of Active Site Models for Oxidized and Reduced Plant-Type Ferrodixins
Crystallographic Studies of Flavodoxins: Some Correlations between Structure and Redox Potential
Evidence that Thenoyltrifluoroacetone Inhibits Reduction of Ubisemiquinone to Ubiquinol but Not Reduction of Ubiquinone to Ubisemiquinone
Enhancement of the Chemiluminescence of Perfused Rat Liver and of Isolated Mitochondria and Microsomes by Hydroperoxides
An Iron-Sulfur Cluster of the Hipip Type as a Component of Aconitase. A New Area of Involvement of Iron-Sulfur Proteins?
Further Observation on a Mitochondrial Metallocompound and on a Ferrous-EDTA-No Model Compound
Ferroactivator Protein Permits Ferrous Ion to Stimulate Phosphoenolpyruvate Carboxykinase
The Structure of Oxy Cobalt Myoglobin at 1.5 Å Resolution
The Iron Atom Displacement in Deoxyhemoglobin: A Spin-State or Nonbonded Repulsion Effect?
Characterization of High-Spin Ferric States in Heme Proteins
Sequence of Oxygen Binding by Hemoglobin
Dichloromethane as a Modulator of Hemoglobin Function
The Structural Determinants of Thermodynamics, Reactivity Differences in Methaemoglobins, and the Variability of Haemoglobin Affinity for Diphosphoglycerate Ion
Structural and Free Energy Changes in Hemoglobin Measured by Hydrogen Exchange Methods
Proton NMR Studies of Hemoproteins Substituted with Cobaltous Porphyrins
Picosecond Transient Absorption Spectra of Hemoglobin
Hemoglobin S Polymerization in the Photostationary State
Exhibition of Delay Time in Aggregation of Deoxy Hb S in Concentrated Phosphate Buffer
Part 5 Structural-Functional Approaches to Membrane Energetics
The Structure and Function of Reconstituted Ca2+ ATPase/Lipid and Photosynthetic Reaction Center/Lipid Membranes
Rhodopsin and Bacteriorhodopsin in Model Membranes
Molecular Biology and Energetics of Active Transport
Mechanism of Free Energy Utilization for Active Transport of Calcium Ion
Zeroing in on the Ionophoric Site of the (Ca2++ Mg2+)-ATPase
Ionic Interactions in the Calcium Conductance of Neurons
Carrier-Mediated Translocation of Cysteinesulfinate Across the Mitochondrial Membrane
Calcium-Anion Symport Systems in Mitochondria
The Regulation of Cytoplasmic Calcium by Liver Mitochodria
Charge and H+/Ca2+ Stoichiometries during Ca2+ Influx and Efflux in Rat Liver Mitochondria
Low Molecular Weight Ca2+-Carrier From Inner Mitochondrial Membrane
The Unique Ability of Picrate to Uncouple Submitochondrial Particles But Not Mitochondria is Consistent with the Chemiosmotic Hypothesis
Amphoteric Complexes of a Neutral Ionophore Having Tertiary Amide Ligands-A Model for Anion Binding to the Polypeptide Backbone
ß-Helical Transmembrane Channels: Comments on Energetics, Structure, Monovalent, and Divalent Cation Selectivity and Voltage Dependence
Interaction of Gramicidin with Monovalent Cations
Cardiovascular Effects of Ionophores
Spin-Probe-Spin-Label Investigations of Model Membranes
Surface Potential Changes and pH Gradients Measured with Paramagnetic Probes in Illuminated Thylakoid Membranes
Proton and Hydroxyl Permeability Coefficients Measured for Unilamellar Liposomes
Control of Interactions of 9-Amino Acridine Derivatives with Beef Heart Submitochondrial Membranes
Potential Sensitive Oxonol Dyes: Model Systems to Organelles
Some Properties of the Extrinsic Probe, Oxonol-V, in Tissues
Potentiometric Probes for Simultaneous Optical Recording From Multiple Sites in Neural Networks
Measurement of Red Blood Cell Membrane Potential by Cyanine Dye Fluorescence
Features and Function of Lateral Motion on Cell Membrane Revealed by Fluorescence Dynamics
Part 6 Nondestructive Measurements of Tissue Function
Creatine Kinase Activities in Skeletal and Cardiac Muscle Measured by Saturation Transfer NMR
31P NMR Studies on Perfused Mouse Liver
A 13C NMR Study of Gluconeogenesis in Isolated Rat Liver Cells
13C NMR Studies of Glycolysis in Suspensions of Escherichia coli Cells
Phosphorus Nuclear Magnetic Resonance of Diseased Muscle
Oxygen Electrodes-A Brief Review
Peroxide and Redox-Coupled Polarographie Enzyme Electrodes
Direct Measurement of Membrane Potential and Resistance in Giant Cells of Escherichia coli
Intracellular K+ Activity in Sheep Cardiac Purkinje Fibers
Pacemaker Currents and Paracellular K+ Accumulation in Rabbit Sinoatrial Node
Measurement of Extracellular Ion Activities ([K+])e, [Na+]e, [Ca2+]e) during Acute Coronary Occlusion
Extracellular Oxygen Gradients in Shock
Noninvasive Monitoring of Human Brain Oxidative Metabolism
Spectrophotometric Monitoring of Cerebral O2 Sufficiency and Circulatory Parameters
Shedding Light on the Awake Brain
Metabolic Responses of the Gerbil Brain Cortex to Anoxia, Spreading Depression, Carotid Occlusion, and Stroke
Two- and Three-Dimensional Redox Heterogeneity of Rat Liver. Effects of Anoxia and Alcohol on the…